Li Yang, Deng You-Bin, Bi Xiao-Jun, Liu Ya-Ni, Zhang Jun, Li Li, Chen Bin
Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Medical Ultrasound, the First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):747-751. doi: 10.1007/s11596-016-1656-x. Epub 2016 Oct 18.
This study evaluated the myocardial strain and aortic elasticity in patients with bicuspid aortic valve (BAV) and then investigated the relation between them. Thirty-nine patients (30 males; mean age 44±19 years; range 6 to 75 years) with BAV were recruited as BAV group, and 29 age- and sex-matched healthy controls (21 males; mean age 42±11 years; range 20 to 71 years) served as control group. Aortic strain, distensibility and stiffness index were derived using M-mode echocardiography. Left ventricular global myocardial strain was acquired with speckle-tracking echocardiography. Correlation between aortic elasticity and myocardial strain was also analyzed. The results showed that aortic stiffness was higher (17.5±14.0 vs. 5.3±2.7, P<0.001), and aortic strain (4.9±4.7 vs. 11.0±4.1, P<0.001) and distensibility (1.8±2.1 vs. 3.7±1.6, P<0.001) were lower significantly in BAV group than in control group. Global circumferential strain (-19.1±4.2 vs.-22.5±3.7, P<0.001), radial stain (29.8±14.9 vs. 38.0±8.8, P<0.001) and longitudinal stain (-18.4±3.4 vs.-20.8±3.5, P<0.001) were significantly lower in BAV group than in control group. There was weak association between aortic elasticity and myocardial strain. These findings indicated BAV patients manifest reduced myocardial strain which had weak relationship with aortic elastic lesion.
本研究评估了二叶式主动脉瓣（BAV）患者的心肌应变和主动脉弹性，然后研究了它们之间的关系。招募了39例BAV患者（30例男性；平均年龄44±19岁；范围6至75岁）作为BAV组，29例年龄和性别匹配的健康对照者（21例男性；平均年龄42±11岁；范围20至71岁）作为对照组。使用M型超声心动图得出主动脉应变、扩张性和僵硬度指数。用斑点追踪超声心动图获取左心室整体心肌应变。还分析了主动脉弹性与心肌应变之间的相关性。结果显示，BAV组的主动脉僵硬度较高（17.5±14.0对5.3±2.7，P<0.001），而主动脉应变（4.9±4.7对11.0±4.1，P<0.001）和扩张性（1.8±2.1对3.7±1.6，P<0.001）显著低于对照组。BAV组的整体圆周应变（-19.1±4.2对-22.5±3.7，P<0.001）、径向应变（29.8±14.9对38.0±8.8，P<0.001）和纵向应变（-18.4±3.4对-20.8±3.5，P<0.001）显著低于对照组。主动脉弹性与心肌应变之间存在弱关联。这些发现表明，BAV患者表现出心肌应变降低，且与主动脉弹性病变关系较弱。
