Wang Ruo-Zheng, Zhang Dian-Gang, Wu Ran, Hu Yun-Hui, Peng Yan-Chun, Chang Cheng, Dong Tao, Wang Xi-Yan
Department of Head and Neck Radiation Oncology, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Department of Oncology, Bazhou People's Hospital of Mongolian Autonomous Prefecture, Kuerle, 841000, China.
J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):700-704. doi: 10.1007/s11596-016-1647-y. Epub 2016 Oct 18.
Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B46 and HLA-A02-B46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A02-B46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS (P=0.032, 0.040, and 0.013, respectively). We found that the HLA-A02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC.
流行病学研究表明，人类白细胞抗原（HLA）等位基因多态性与鼻咽癌（NPC）易感性密切相关，并且在之前的一项研究中，我们发现HLA - B46和HLA - A02 - B46单倍型与NPC易感性密切相关。在这项回顾性研究中，我们调查了HLA - A和HLA - B等位基因及单倍型的表型，并将这些数据与NPC的临床和病理参数相关联，以了解HLA等位基因和单倍型在NPC预后中的作用。该队列包括来自新疆汉族人群的117例NPC患者，并分析了局部无复发生存率（LRFS）、远处无转移生存率（DMFS）、无病生存率（DFS）和总生存率（OS）。HLA - A02 - B46单倍型携带者和非携带者的5年DMFS分别为66.4%和90.3%。此外，年龄被发现是LRFS、DFS和OS 的一个预后因素（分别为P = 0.032、0.040和0.013）。我们发现，除了传统的TNM分期外，HLA - A02 - B*46单倍型可能是NPC患者的一个预后标志物。
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