Orlowski W A
J Dent Res. 1978 Feb;57(2):329-33. doi: 10.1177/00220345780570023101.
The remodeling of gingival tissue was measured by determining the incorporation of tritiated proline and the disappearance of tritium activity from proline and hydroxyproline for 18 days after administration of label. There was a rapid decrease in the tritium activity from gingiva which was paralleled by a decrease in the total activity of proline. The activity in collagen decreased sharply between the second and the fourth day but thereafter there was no change. The relative amount of activity increased from 24% at day 2 to 82% at 18 days postinjection, and as a result the specific activities of hydroxyproline and proline were similar after 12 days. Thus collagen appeared to be the more stable component in the gingivae than previously reported. However, the rapid loss of label in the first four days suggested that there may be very marked regional variation in the metabolism of collagen and that more than one metabolic pool of collagen was present.
通过测定氚标记脯氨酸的掺入量以及给药后18天内脯氨酸和羟脯氨酸中氚活性的消失情况来测量牙龈组织的重塑。牙龈中氚活性迅速下降，同时脯氨酸的总活性也下降。胶原蛋白中的活性在第二天到第四天之间急剧下降，但此后没有变化。活性的相对量从注射后第2天的24%增加到第18天的82%，因此12天后羟脯氨酸和脯氨酸的比活性相似。因此，胶原蛋白似乎是牙龈中比之前报道更稳定的成分。然而，前四天标记的快速丢失表明胶原蛋白的代谢可能存在非常明显的区域差异，并且存在不止一个胶原蛋白代谢池。
