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1994年至2013年间芬兰冠状动脉血运重建的发生率、患者选择及预后趋势:心血管疾病登记研究

Trends in rates, patient selection and prognosis of coronary revascularisations in Finland between 1994 and 2013: the CVDR.

作者信息

Kiviniemi Tuomas O, Pietilä Arto, Gunn Jarmo M, Aittokallio Jenni M, Mähönen Markku S, Salomaa Veikko V, Niiranen Teemu J

机构信息

Heart Centre, Turku University Hospital and University of Turku, Turku, Finland.

出版信息

EuroIntervention. 2016 Oct 20;12(9):1117-1125. doi: 10.4244/EIJV12I9A183.

Abstract

AIMS

The aim of the study was to investigate the 20-year trends in rates, patient selection and prognosis of coronary revascularisations in Finland.

METHODS AND RESULTS

We identified patients from nationwide registers who had undergone first-ever percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) between 1994 and 2013. We examined changes in procedure rates, patient characteristics and estimated hazard ratios (HR) and 95% confidence intervals for cardiovascular events during this period. Between 1994 and 2013, 85,482 PCIs and 74,338 CABGs were performed. During this period, PCI rates more than quadrupled while CABG rates declined by two thirds. Between 1994-1998 and 2009-2013, the proportion of urgent procedures and mean patient age increased while the proportion of women remained stable. Although unadjusted mortality rose, the multivariable-adjusted HRs for 28-day mortality (PCI: 0.62 [0.49-0.79]; CABG: 0.62 [0.54-0.72]) and five-year incidence of cardiovascular death (PCI: 0.72 [0.66-0.80]; CABG: 0.77 [0.72-0.83]), myocardial infarction (PCI: 0.47 [0.44-0.50]; CABG: 0.31 [0.29-0.32]) and stroke (PCI: 0.37 [0.34-0.40]; CABG: 0.36 [0.33-0.38]) were lower in the last five-year period than in the period 1994-1998.

CONCLUSIONS

Although revascularisation patients are older than before, post-procedural prognosis has improved drastically in recent years. Understanding the changing characteristics and prognosis of these patients is important for the interpretation of previous and future studies.

摘要

目的

本研究旨在调查芬兰冠状动脉血运重建术的发生率、患者选择及预后的20年趋势。

方法与结果

我们从全国登记册中识别出1994年至2013年间首次接受经皮冠状动脉介入治疗(PCI)或冠状动脉旁路移植术(CABG)的患者。我们研究了在此期间手术率、患者特征的变化,以及心血管事件的估计风险比(HR)和95%置信区间。1994年至2013年间,共进行了85482例PCI和74338例CABG。在此期间,PCI率增长了四倍多,而CABG率下降了三分之二。在1994 - 1998年和2009 - 2013年期间,急诊手术的比例和患者平均年龄增加,而女性比例保持稳定。尽管未调整的死亡率有所上升,但28天死亡率(PCI:0.62 [0.49 - 0.79];CABG:0.62 [0.54 - 0.72])以及心血管死亡、心肌梗死(PCI:0.47 [0.44 - 0.50];CABG:0.31 [0.29 - 0.32])和中风(PCI:0.37 [0.34 - 0.40];CABG:0.36 [0.33 - 0.38])的五年发生率在最后五年期间低于1994 - 1998年期间。

结论

尽管血运重建患者比以前年龄更大,但近年来术后预后有了显著改善。了解这些患者不断变化的特征和预后对于解释既往和未来的研究很重要。

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