罗托昔德和水解酶并不能减轻马拉松引起的炎症。

Rutoside and Hydrolytic Enzymes Do Not Attenuate Marathon-Induced Inflammation.

机构信息

1Department of Prevention, Rehabilitation and Sports Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, GERMANY; 2Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, GERMANY; 3Institute for Laboratory Medicine, Deutsches Herzzentrum Muenchen der Technischen Universitaet Muenchen, Munich, GERMANY; 4Human Performance Laboratory, Appalachian State University and the North Carolina Research Campus, Kannapolis, NC; 5DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, GERMANY; and 6Else Kröner-Fresenius-Zentrum, Klinikum rechts der Isar der Technischen Universität München, Munich, GERMANY.

出版信息

Med Sci Sports Exerc. 2017 Mar;49(3):387-395. doi: 10.1249/MSS.0000000000001116.

DOI:10.1249/MSS.0000000000001116

PMID:27753739

Abstract

INTRODUCTION

Vigorous and prolonged exercise such as marathon running increases inflammatory markers and the risk of upper respiratory illness (URI) in athletes. Nutritional supplements are being tested as countermeasures of exercise-induced inflammation and immune dysfunction.

METHODS

In this prospective randomized, double-blind, placebo-controlled phase I trial, healthy male runners (N = 138, age 42 ± 11 yr) were supplemented with rutoside (600-1200 mg·d) and hydrolytic enzymes (540-1080 mg·d bromelain, 288-576 mg·d trypsin) (WOB) or placebo (PL) for 1 wk before and 2 wk after the Munich Marathon 2013. Blood samples were collected 5 wk prerace and immediately, 24 h, and 72 h postrace and analyzed for inflammation biomarkers (interleukins [IL] 6 and 10, high-sensitivity C-reactive protein, and leukocytes). URI rates, assessed by the Wisconsin Upper Respiratory Symptom Survey, were compared between the study groups during the 2-wk period after the marathon race. URI was defined if the Wisconsin Upper Respiratory Symptom Survey score was equal or greater than seven, representing either one severe symptom or seven mild symptoms.

RESULTS

Immediately postrace, the increase of IL-6 was not significantly different between the WOB and the PL groups (median [interquartile range]: WOB, 33.8 [22.5-58.8] ng·L; PL, 35.6 [24.8-61.29] ng·L; P = 0.758). No significant group differences were observed for increases of IL-10, high-sensitivity C-reactive protein, or leukocytes pre- to postrace (all P > 0.05). From race day until 2 wk after the marathon race, the percentage of individuals with at least one URI did not significantly differ between the groups (WOB, 50.0%; PL, 51.5%; P = 0.859).

CONCLUSION

Supplementation with rutoside and hydrolytic enzymes before and after a marathon race did not attenuate postrace inflammation or decrease URI incidence in nonelite male marathon runners.

摘要

简介

剧烈和长时间的运动，如马拉松跑步，会增加运动员的炎症标志物和上呼吸道疾病（URI）的风险。营养补充剂正被测试作为对抗运动引起的炎症和免疫功能障碍的方法。

方法

在这项前瞻性随机、双盲、安慰剂对照的 I 期试验中，健康的男性跑步者（N=138，年龄 42±11 岁）在 2013 年慕尼黑马拉松赛前 1 周和赛后 2 周内分别补充 rutoside（600-1200mg·d）和水解酶（540-1080mg·d 菠萝蛋白酶，288-576mg·d 胰蛋白酶）（WOB）或安慰剂（PL）。在比赛前 5 周、比赛后立即、24 小时和 72 小时采集血液样本，并分析炎症生物标志物（白细胞介素[IL]6 和 10、高敏 C 反应蛋白和白细胞）。通过威斯康星州上呼吸道症状调查评估 URI 发生率，并在马拉松赛后 2 周内比较研究组之间的差异。如果威斯康星州上呼吸道症状调查评分等于或大于 7，则定义为 URI，代表一个严重症状或七个轻度症状。

结果

比赛后立即，WOB 和 PL 组之间的 IL-6 增加没有显著差异（中位数[四分位间距]：WOB，33.8[22.5-58.8]ng·L；PL，35.6[24.8-61.29]ng·L；P=0.758）。从赛前到赛后，IL-10、高敏 C 反应蛋白或白细胞的增加没有明显的组间差异（所有 P>0.05）。从比赛日到马拉松赛后 2 周，两组至少有一人出现 URI 的百分比没有显著差异（WOB，50.0%；PL，51.5%；P=0.859）。