某些1,3,4-噻二唑衍生物的合成与降压活性
Synthesis and antihypertensive activity of some 1,3,4-thiadiazole derivatives.
作者信息
Vio L, Mamolo M G, Laneve A
机构信息
Istituto Di Chimica Farmaceutica, Universita Di Trieste, Italy.
出版信息
Farmaco. 1989 Feb;44(2):165-72. doi: 10.1002/chin.198939181.
PMID:2775413
Abstract
A series of 2-arylamino-1,3,4-thiadiazole derivatives was synthesized with the aim to find new antihypertensive compounds. The antihypertensive activity of some of these compounds was examined intraperitoneally in conscious spontaneously hypertensive rats (SHR). The tested compounds showed activity, but none of these possessed a higher potency than the reference substance guanabenz.
摘要
合成了一系列2-芳氨基-1,3,4-噻二唑衍生物，目的是寻找新的抗高血压化合物。在清醒的自发性高血压大鼠（SHR）中通过腹腔注射检测了其中一些化合物的抗高血压活性。测试的化合物显示出活性，但这些化合物的效力均不高于参比物质胍那苄。
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