节前神经去支配后自发性高血压大鼠和Wistar-Kyoto大鼠颈上神经节中的血管紧张素II结合位点

Angiotensin II binding sites in the superior cervical ganglia of spontaneously hypertensive and Wistar-Kyoto rats after preganglionic denervation.

作者信息

Pinto J E, Nazarali A J, Saavedra J M

机构信息

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892.

出版信息

Am J Hypertens. 1989 Aug;2(8):647-9. doi: 10.1093/ajh/2.8.647.

DOI:10.1093/ajh/2.8.647

PMID:2775508

Abstract

In the superior cervical ganglia (SCG) binding site density of angiotensin II (ANG II) was higher in adult spontaneously hypertensive rats (SHR) (571 +/- 29 fmol/mg protein) compared to that in the adult Wistar-Kyoto rat (WKY) (375 +/- 9 fmol/mg protein, P less than 0.05). The ANG II binding density was significantly decreased in the SCG of SHR (-59%, P less than 0.01) and of WKY (-39%, P less than 0.05) after unilateral preganglionic denervation (operated v sham-operated ganglia). Part of the binding sites in the superior cervical ganglia may be present in or be associated to preganglionic nerves, and the number of these sites is higher in SHR.

摘要

与成年Wistar-Kyoto大鼠（WKY）（375±9 fmol/mg蛋白）相比，成年自发性高血压大鼠（SHR）颈上神经节（SCG）中血管紧张素II（ANG II）的结合位点密度更高（571±29 fmol/mg蛋白，P<0.05）。单侧节前神经切断术后（手术侧神经节与假手术侧神经节相比），SHR的SCG中ANG II结合密度显著降低（-59%，P<0.01），WKY的SCG中ANG II结合密度也显著降低（-39%，P<0.05）。颈上神经节中的部分结合位点可能存在于节前神经内或与节前神经相关，且这些位点的数量在SHR中更多。