节前神经去支配后自发性高血压大鼠和Wistar-Kyoto大鼠颈上神经节中的血管紧张素II结合位点

Angiotensin II binding sites in the superior cervical ganglia of spontaneously hypertensive and Wistar-Kyoto rats after preganglionic denervation.

作者信息

Pinto J E, Nazarali A J, Saavedra J M

机构信息

Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Brain Res. 1988 Dec 13;475(1):146-50. doi: 10.1016/0006-8993(88)90208-9.

DOI:10.1016/0006-8993(88)90208-9

PMID:3214721

Abstract

Angiotensin II binding was higher in superior cervical ganglia of adult spontaneously hypertensive rats (SHR) when compared to ganglia of Wistar-Kyoto (WKY) rats (571 +/- 29 and 375 +/- 9 fmol/mg protein, SHR and WKY, respectively, P less than 0.05). Unilateral preganglionic denervation reduced binding site density in ganglia of WKY (-39%, P less than 0.05 vs sham operated ganglia in WKY), and the decrease of binding sites was larger in SHR (-59%, P less than 0.01, operated vs sham operated ganglia in SHR). Part of the binding sites in the superior cervical ganglia may be present in or be associated to preganglionic nerves, and the number of these sites is higher in SHR.

摘要

与Wistar-Kyoto（WKY）大鼠的神经节相比，成年自发性高血压大鼠（SHR）颈上神经节中的血管紧张素II结合水平更高（分别为571±29和375±9 fmol/mg蛋白，SHR和WKY，P<0.05）。单侧节前神经去神经支配降低了WKY大鼠神经节中的结合位点密度（-39%，与WKY假手术神经节相比，P<0.05），且SHR中结合位点的减少幅度更大（-59%，SHR手术组与假手术组相比，P<0.01）。颈上神经节中的部分结合位点可能存在于节前神经中或与节前神经相关，且SHR中这些位点的数量更多。