Suh Man Koon, Lee Kyo Ho, Harijan Aram, Kim Hyung-Gu, Jeong Euicheol C
*JW Plastic Surgery Center †CBK Plastic Surgery Clinic ‡Well Plastic Surgery Clinic, Seoul §L&C BIO Co/R&D Center, Seongnam ||Department of Plastic Surgery, SMG-SNU Boramae Medical Center ¶Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Korea.
J Craniofac Surg. 2017 Mar;28(2):445-448. doi: 10.1097/SCS.0000000000003225.
Alloplastic materials are a mainstay in Asian rhinoplasty. However, the outline of alloplastic implants can become conspicuous over time in rhinoplasty patients, which is a significant cause for revision. In revision rhinoplasty, alloplastic materials can remain a viable and affordable option in Asian patients. The acellular dermal matrices (ADM) are often used to interface between the silicone material and the skin envelope. This study assesses histologic changes following implantation of ADM-covered silicone material in rats.
To demonstrate differences at the histologic level, silicone blocks with and without ADM were implanted in the subcutaneous plane of 10 rats. These implants were harvested after 9 weeks and examined histologically for capsule thickness and myofibroblast activity.
In the in vivo study, the presence of ADM was associated with significantly decreased capsule thickness and myofibroblast activity around the implant and maintained the structure of ADM well.
The authors suggest that using the ADMs to cover silicone implants can be an alternative method for decreasing the visibility of implant contour, by the prevention of capsular contracture and the addition of a soft tissue layer to the dorsal skin envelope.
异体材料是亚洲鼻整形术中的主要材料。然而，在鼻整形患者中，异体植入物的轮廓会随着时间推移变得明显，这是进行修复手术的一个重要原因。在鼻修复整形术中，异体材料对亚洲患者而言仍是一种可行且经济的选择。脱细胞真皮基质（ADM）常用于硅酮材料与皮肤包膜之间。本研究评估大鼠植入ADM覆盖的硅酮材料后的组织学变化。
为了在组织学水平上证明差异，将有无ADM的硅酮块植入10只大鼠的皮下平面。9周后取出这些植入物，进行组织学检查以测量包膜厚度和成肌纤维细胞活性。
在体内研究中，ADM的存在与植入物周围包膜厚度和成肌纤维细胞活性显著降低相关，并且能很好地保持ADM的结构。
作者认为，使用ADM覆盖硅酮植入物可以作为一种替代方法，通过预防包膜挛缩和在鼻背皮肤包膜增加一层软组织层来减少植入物轮廓的可见度。
