Miyazaki Yusuke, Katanasaka Yasufumi, Sunagawa Yoichi, Hirano-Sunagawa Sae, Funamoto Masafumi, Morimoto Eriko, Komiyama Maki, Shimatsu Akira, Satoh-Asahara Noriko, Yamakage Hajime, Wada Hiromichi, Hasegawa Koji, Morimoto Tatsuya
Division of Molecular Medicine, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Division of Molecular Medicine, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Shizuoka General Hospital, Shizuoka, Japan; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Int J Cardiol. 2016 Dec 15;225:332-336. doi: 10.1016/j.ijcard.2016.09.116. Epub 2016 Oct 3.
HMG-CoA reductase inhibitors, also termed statins, are used to reduce the risk of coronary artery disease. Two oxidatively modified low-density lipoprotein (LDL) complexes, serum amyloid A-LDL (SAA-LDL) and α1-antitrypsin-LDL (AT-LDL), serve as atherosclerotic, inflammatory, and cardiovascular risk markers. In this study, we examined the effects of hydrophilic rosuvastatin (RSV) and lipophilic pitavastatin (PTV) on these markers in patients with hypercholesterolemia.
The present study was a sub-analysis of our previous STAT-LVDF study. The subjects were treated with RSV or PTV for 24weeks. Changes in glucose-lipid metabolism, serum levels of SAA-LDL and AT-LDL, and C-reactive protein (CRP) level were assessed.
In total, 53 patients were analyzed in the present study. RSV and PTV significantly decreased SAA-LDL (RSV: p=0.003, PTV: p=0.012) and AT-LDL levels (RSV: p=0.013, PTV: p=0.037). Changes in SAA-LDL level were significantly and positively correlated with those in CRP in both the RSV (r=0.549, p=0.003) and PTV (r=0.576, p=0.004) groups. Moreover, a positive correlation between changes of SAA-LDL levels and those of HbA1c levels was observed in the PTV group (r=0.442, p=0.030) but not in the RSV group (r=-0.100, p=0.611).
Both hydrophilic rosuvastatin and lipophilic pitavastatin reduce serum levels of atherosclerotic and inflammatory markers. These findings also indicate differential effects of RSV and PTV on glucose tolerance.
HMG-CoA还原酶抑制剂，也称为他汀类药物，用于降低冠状动脉疾病风险。两种氧化修饰的低密度脂蛋白（LDL）复合物，血清淀粉样蛋白A-LDL（SAA-LDL）和α1-抗胰蛋白酶-LDL（AT-LDL），作为动脉粥样硬化、炎症和心血管疾病风险标志物。在本研究中，我们研究了亲水性瑞舒伐他汀（RSV）和亲脂性匹伐他汀（PTV）对高胆固醇血症患者这些标志物的影响。
本研究是我们之前STAT-LVDF研究的子分析。受试者接受RSV或PTV治疗24周。评估糖脂代谢、SAA-LDL和AT-LDL血清水平以及C反应蛋白（CRP）水平的变化。
本研究共分析了53例患者。RSV和PTV显著降低了SAA-LDL（RSV：p = 0.003，PTV：p = 0.012）和AT-LDL水平（RSV：p = 0.013，PTV：p = 0.037）。在RSV组（r = 0.549，p = 0.003）和PTV组（r = 0.576，p = 0.004）中，SAA-LDL水平的变化与CRP的变化均呈显著正相关。此外，在PTV组中观察到SAA-LDL水平变化与糖化血红蛋白（HbA1c）水平变化之间呈正相关（r = 0.442，p = 0.030），而在RSV组中未观察到（r = - 0.100，p = 0.611）。
亲水性瑞舒伐他汀和亲脂性匹伐他汀均可降低动脉粥样硬化和炎症标志物的血清水平。这些发现还表明RSV和PTV对葡萄糖耐量有不同影响。
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