Ösken Altuğ, Yelgeç Nizamettin Selçuk, Zehir Regayip, Öz Tuğba Kemaloğlu, Yaylacı Selçuk, Akdemir Ramazan, Gündüz Hüseyin
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.
Department of Internal Medicine, Rize Findikli Goiter Research Center, Rize, Turkey.
Indian J Pharmacol. 2016 Jul-Aug;48(4):462-465. doi: 10.4103/0253-7613.186193.
Drug-induced torsades de pointes (TdP) is a rare but potentially fatal adverse effect of commonly prescribed medications including cardiac and noncardiac drugs. Importantly, many drugs have been reported to cause the characteristic Brugada syndrome-linked electrocardiography (ECG) abnormalities and/or (fatal) ventricular tachyarrhythmias. Chlorpheniramine and propranolol have the arrhythmogenic effects reported previously. A review of literature revealed a large number of case reports of chlorpheniramine or propranolol use resulting in QTc prolongation, TdP, or both. However, we wish to report the case of a patient who was treated with a combination of chlorpheniramine and propranolol, whose ECG showed no QT prolongation but who suffered from cardiac arrest due to TdP.
药物性尖端扭转型室速（TdP）是包括心脏和非心脏药物在内的常用处方药罕见但可能致命的不良反应。重要的是，许多药物已被报道可导致特征性的与Brugada综合征相关的心电图（ECG）异常和/或（致命性）室性快速心律失常。氯苯那敏和普萘洛尔先前已有致心律失常作用的报道。文献综述显示有大量关于使用氯苯那敏或普萘洛尔导致QTc延长、TdP或两者皆有的病例报告。然而，我们希望报告一例患者，该患者接受氯苯那敏和普萘洛尔联合治疗，其心电图显示无QT延长，但因TdP发生心脏骤停。
