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本文引用的文献

1
Drug treatments in people with intellectual disability and challenging behaviour.针对智力残疾和具有挑战性行为人群的药物治疗。
BMJ. 2014 Jul 4;349:g4323. doi: 10.1136/bmj.g4323.
2
Characteristics and the trajectory of psychotropic medication use in general and antipsychotics in particular among adults with an intellectual disability who exhibit aggressive behaviour.有攻击行为的成年智障者使用精神药物尤其是抗精神病药物的特征及用药轨迹。
J Intellect Disabil Res. 2015 Jan;59(1):11-25. doi: 10.1111/jir.12119. Epub 2014 Jan 22.
3
Aripiprazole for autism spectrum disorders (ASD).阿立哌唑用于治疗自闭症谱系障碍(ASD)。
Cochrane Database Syst Rev. 2012 May 16(5):CD009043. doi: 10.1002/14651858.CD009043.pub2.
4
International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities.国际成人智力残疾患者问题行为管理精神药物处方指南。
World Psychiatry. 2009 Oct;8(3):181-6. doi: 10.1002/j.2051-5545.2009.tb00248.x.
5
Risperidone, haloperidol, and placebo in the treatment of aggressive challenging behaviour in patients with intellectual disability: a randomised controlled trial.利培酮、氟哌啶醇与安慰剂治疗智力残疾患者攻击性行为的随机对照试验
Lancet. 2008 Jan 5;371(9606):57-63. doi: 10.1016/S0140-6736(08)60072-0.
6
Risperidone for autism spectrum disorder.利培酮用于治疗自闭症谱系障碍。
Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD005040. doi: 10.1002/14651858.CD005040.pub2.
7
Psychopathology in children and adolescents with autism compared to young people with intellectual disability.与智力残疾青少年相比,自闭症儿童和青少年的精神病理学。
J Autism Dev Disord. 2006 Oct;36(7):863-70. doi: 10.1007/s10803-006-0125-y.
8
Pharmacological management of challenging behavior of individuals with intellectual disability.智力残疾个体挑战性行为的药物治疗
Res Dev Disabil. 2004 Nov-Dec;25(6):523-37. doi: 10.1016/j.ridd.2004.03.001.
9
People with intellectual disabilities.智障人士。
BMJ. 2004 Aug 21;329(7463):414-5. doi: 10.1136/bmj.329.7463.414.
10
Antipsychotic medication for challenging behaviour in people with learning disability.用于治疗学习障碍患者挑战性行为的抗精神病药物
Cochrane Database Syst Rev. 2004;2004(3):CD000377. doi: 10.1002/14651858.CD000377.pub2.

为成年智障者开具精神药物处方。

Prescribing psychotropic drugs to adults with an intellectual disability.

作者信息

Trollor Julian N, Salomon Carmela, Franklin Catherine

机构信息

Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Australia, Sydney.

Queensland Centre for Intellectual and Developmental Disability Mater Research Institute - University of Queensland, Brisbane.

出版信息

Aust Prescr. 2016 Aug;39(4):126-130. doi: 10.18773/austprescr.2016.048. Epub 2016 Aug 1.

DOI:10.18773/austprescr.2016.048
PMID:27756975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4993707/
Abstract

Mental illness is common in people with intellectual disability. They may also have physical health problems which can affect their mental state. Difficulties in communication can contribute to mental health problems being overlooked. These may present with changes in behaviour. Psychological management is usually preferable to prescribing psychotropic drugs. Behavioural approaches are the most appropriate way to manage challenging behaviour. If a drug is considered, prescribers should complete a thorough diagnostic assessment, exclude physical and environmental contributions to symptoms, and consider medical comorbidities before prescribing. Where possible avoid psychotropics with the highest cardiometabolic burden. Prescribe the minimum effective dose and treatment length, and regularly monitor drug efficacy and adverse effects. There is insufficient evidence to support the use of psychotropics for challenging behaviour. They should be avoided unless the behaviour is severe and non-responsive to other treatments.

摘要

精神疾病在智力残疾者中很常见。他们也可能有身体健康问题,这会影响他们的精神状态。沟通困难可能导致心理健康问题被忽视。这些问题可能表现为行为改变。心理管理通常比开精神药物更可取。行为方法是管理具有挑战性的行为的最合适方式。如果考虑使用药物,开处方者应进行全面的诊断评估,排除身体和环境对症状的影响,并在开处方前考虑合并症。尽可能避免使用心脏代谢负担最高的精神药物。开出最低有效剂量和治疗时长,并定期监测药物疗效和不良反应。没有足够的证据支持使用精神药物来应对具有挑战性的行为。除非行为严重且对其他治疗无反应,否则应避免使用。