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1
When conventional treatment fails: the role of intravenous immunoglobulin in recurrent pregnancy loss secondary to antiphospholipid syndrome.当传统治疗失败时：静脉注射免疫球蛋白在抗磷脂综合征继发复发性流产中的作用。
Obstet Med. 2013 Jun;6(2):76-79. doi: 10.1177/1753495X12472644. Epub 2013 May 3.
2
Intravenous immunoglobulins and antiphospholipid syndrome: How, when and why? A review of the literature.静脉注射免疫球蛋白与抗磷脂综合征：如何、何时及为何应用？文献复习。
Autoimmun Rev. 2016 Mar;15(3):226-35. doi: 10.1016/j.autrev.2015.11.009. Epub 2015 Dec 1.
3
Utilization of intravenous immunoglobulin therapy to treat recurrent pregnancy loss in the antiphospholipid syndrome: a review.静脉注射免疫球蛋白疗法治疗抗磷脂综合征复发性流产的研究综述
Scand J Rheumatol Suppl. 1998;107:97-102. doi: 10.1080/03009742.1998.11720777.
4
Intravenous immunoglobulin therapy of antiphospholipid syndrome.抗磷脂综合征的静脉注射免疫球蛋白治疗
Rheumatology (Oxford). 2000 Apr;39(4):421-6. doi: 10.1093/rheumatology/39.4.421.
5
Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies.皮下注射低分子量肝素加阿司匹林与静脉注射免疫球蛋白治疗抗磷脂抗体相关复发性流产的随机研究。
Arthritis Rheum. 2003 Mar;48(3):728-31. doi: 10.1002/art.10957.
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Intravenous immunoglobulin for the secondary prevention of stillbirth in obstetric antiphospholipid syndrome: A case series and systematic review of literature.静脉注射免疫球蛋白用于产科抗磷脂综合征中死胎的二级预防：病例系列和文献系统评价。
Autoimmun Rev. 2020 Sep;19(9):102620. doi: 10.1016/j.autrev.2020.102620. Epub 2020 Jul 16.
7
A case of successful pregnancy following multidrug treatment including rituximab and intravenous immunoglobulin for primary antiphospholipid antibody syndrome refractory to conventional treatment.例：1 例原发性抗磷脂抗体综合征患者经利妥昔单抗和静脉注射免疫球蛋白联合多种药物治疗后成功妊娠，该患者对常规治疗无效。
Mod Rheumatol Case Rep. 2020 Jan;4(1):47-50. doi: 10.1080/24725625.2019.1648633. Epub 2019 Aug 6.
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A favorable outcome of pregnancies in women with primary and secondary recurrent pregnancy loss associated with antiphospholipid syndrome.
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Comparison of therapeutic interventions for recurrent pregnancy loss in association with antiphospholipid syndrome: A systematic review and network meta-analysis.抗磷脂抗体综合征相关复发性妊娠丢失的治疗干预措施比较：系统评价和网络荟萃分析。
Am J Reprod Immunol. 2020 Apr;83(4):e13219. doi: 10.1111/aji.13219. Epub 2020 Jan 28.
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The efficacy and safety of second-line treatments of refractory and/or high risk pregnant antiphospholipid syndrome patients. A systematic literature review analyzing 313 pregnancies.抗磷脂抗体综合征难治性和/或高危孕妇二线治疗的疗效和安全性：系统文献复习分析 313 例妊娠。
Semin Arthritis Rheum. 2021 Feb;51(1):28-35. doi: 10.1016/j.semarthrit.2020.10.001. Epub 2020 Dec 17.

引用本文的文献

1
Combined detection of anticardiolipin and anti-β2-glycoprotein 1 antibodies may predict pregnancy outcome.抗心磷脂抗体和抗β2糖蛋白1抗体联合检测可能预测妊娠结局。
Am J Transl Res. 2022 Mar 15;14(3):1750-1756. eCollection 2022.

本文引用的文献

1
Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome.依诺肝素与普通肝素治疗抗磷脂抗体综合征所致复发性流产的疗效比较。
Int J Gynaecol Obstet. 2011 Mar;112(3):211-5. doi: 10.1016/j.ijgo.2010.09.010. Epub 2011 Jan 19.
2
Efficacy and safety of two doses of low molecular weight heparin (enoxaparin) in pregnant women with a history of recurrent abortion secondary to antiphospholipid syndrome.两剂低分子量肝素（依诺肝素）用于抗磷脂综合征继发复发性流产孕妇的疗效与安全性。
J Obstet Gynaecol. 2010;30(8):842-6. doi: 10.3109/01443615.2010.518651.
3
Antiphospholipid syndrome.抗磷脂综合征。
Lancet. 2010 Oct 30;376(9751):1498-509. doi: 10.1016/S0140-6736(10)60709-X. Epub 2010 Sep 6.
4
Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view.抗磷脂抗体介导的胎儿丢失：从发病机制角度看仍是一个未解决的问题。
Lupus. 2010 Apr;19(4):453-6. doi: 10.1177/0961203309361351.
5
Obstetric antiphospholipid syndrome: current uncertainties should guide our way.产科抗磷脂综合征：当前的不确定性应指引我们前进。
Lupus. 2010 Apr;19(4):446-52. doi: 10.1177/0961203310361490.
6
Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression.肝素和阿司匹林联合治疗优于单独使用阿司匹林，可提高复发性流产且抗磷脂抗体阳性患者的活产率：一项随机对照试验的荟萃分析和荟萃回归。
Rheumatology (Oxford). 2010 Feb;49(2):281-8. doi: 10.1093/rheumatology/kep373. Epub 2009 Dec 4.
7
Anti-phospholipid antibodies and other immunological causes of recurrent foetal loss--a review of literature of various therapeutic protocols.抗磷脂抗体及复发性流产的其他免疫原因——各种治疗方案的文献综述
Am J Reprod Immunol. 2009 Jul;62(1):9-24. doi: 10.1111/j.1600-0897.2009.00714.x.
8
Low-molecular-weight heparin versus intravenous immunoglobulin for recurrent abortion associated with antiphospholipid antibody syndrome.低分子量肝素与静脉注射免疫球蛋白治疗抗磷脂抗体综合征相关复发性流产的比较
Int J Gynaecol Obstet. 2009 Mar;104(3):223-5. doi: 10.1016/j.ijgo.2008.11.010. Epub 2008 Dec 29.
9
Pregnancy and catastrophic antiphospholipid syndrome.妊娠与灾难性抗磷脂综合征
Clin Rev Allergy Immunol. 2009 Jun;36(2-3):85-90. doi: 10.1007/s12016-008-8100-3.
10
Management of the controversial aspects of the antiphospholipid syndrome pregnancies: a guide for clinicians and researchers.抗磷脂综合征妊娠争议问题的管理：临床医生和研究人员指南
Rheumatology (Oxford). 2008 Jun;47 Suppl 3:iii23-7. doi: 10.1093/rheumatology/ken181.

当传统治疗失败时：静脉注射免疫球蛋白在抗磷脂综合征继发复发性流产中的作用。

When conventional treatment fails: the role of intravenous immunoglobulin in recurrent pregnancy loss secondary to antiphospholipid syndrome.

作者信息

Chay Jacklyn, Lust Karin, Kubler Paul, Callaway Leonie

机构信息

Greenslopes Private Hospital, Newdegate St, Greenslopes, Qld 4102.

Royal Brisbane and Women's Hospital, Butterfield St, Herston, Qld 4029, Australia.

出版信息

Obstet Med. 2013 Jun;6(2):76-79. doi: 10.1177/1753495X12472644. Epub 2013 May 3.

DOI:10.1177/1753495X12472644
PMID:27757161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5052759/
Abstract

Recurrent pregnancy loss (RPL) is a well-recognized complication of antiphospholipid syndrome (APS). First line therapy consists of low dose aspirin and heparin. Despite conventional therapy some women fail to achieve a successful pregnancy outcome. We describe the case of a patient who had two live births following intravenous immunoglobulin therapy despite previous failure with conventional therapy for RPL in the setting of APS. We will summarize the available literature on intravenous immunoglobulin for this indication.

摘要

复发性流产（RPL）是抗磷脂综合征（APS）一种公认的并发症。一线治疗包括低剂量阿司匹林和肝素。尽管采用了传统疗法，但仍有一些女性未能获得成功的妊娠结局。我们描述了一例患者，尽管此前在APS背景下采用传统疗法治疗RPL失败，但在接受静脉注射免疫球蛋白治疗后成功产下两名活婴。我们将总结关于静脉注射免疫球蛋白用于该适应症的现有文献。