Antonioli Luca, Blandizzi Corrado, Malavasi Fabio, Ferrari Davide, Haskó György
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; Department of Surgery and Center for Immunity and Inflammation, Rutgers-New Jersey Medical School, Newark, NJ, USA.
Department of Clinical and Experimental Medicine, University of Pisa , Pisa, Italy.
Oncoimmunology. 2016 Jul 29;5(9):e1216292. doi: 10.1080/2162402X.2016.1216292. eCollection 2016.
The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.
胞外5'-核苷酸酶/CD73酶在生成富含腺苷的免疫抑制和促血管生成微环境以支持癌症发展方面发挥着关键作用。靶向CD73会导致肿瘤微环境的重组,塑造浸润性T细胞的表型。CD73单克隆抗体的研发为抗肿瘤治疗提供了一条充满希望的新途径。