Kojima Yoko, Okudela Koji, Matsumura Mai, Omori Takahiro, Baba Tomohisa, Sekine Akimasa, Woo Tetsukan, Umeda Shigeaki, Takemura Tamiko, Mitsui Hideaki, Suzuki Takehisa, Tateishi Yoko, Iwasawa Tae, Arai Hiromasa, Tajiri Michihiko, Ogura Takashi, Kameda Yoichi, Masuda Munetaka, Ohashi Kenich
Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Histopathology. 2017 Mar;70(4):568-578. doi: 10.1111/his.13103. Epub 2016 Dec 23.
To investigate the pathological features of idiopathic interstitial pneumonia (IIP)-associated pulmonary adenocarcinoma.
Surgically resected adenocarcinomas associated with IIP (the IIP group) and adenocarcinomas without IIP (the non-IIP group) were subjected to analysis. Adenocarcinomas in the IIP group were subdivided into two groups: one group included tumours connected to bronchiolar metaplasia in honeycomb lesions (the H-IIP group), and the other included tumours unrelated to honeycomb lesions (the NH-IIP group). Histomorphological appearance and immunohistochemical expression were compared among the H-IIP group, the NH-IIP group, and the non-IIP group. Most of the tumour cells in the H-IIP group had a tall, columnar shape that showed similar features to proximal bronchial epithelium, whereas tumour cells in the NH-IIP group and the non-IIP group had a club-like shape that showed similar features to respiratory bronchiolar/alveolar epithelium. Adenocarcinomas in the H-IIP group tended to be negative for thyroid transcription factor-1 (TTF-1) and positive for hepatocyte nuclear factor-4α (HNF-4α). The frequency of EGFR mutations was significantly lower in adenocarcinomas in the H-IIP group, although the frequencies of KRAS and ALK mutations did not differ among the three groups.
Idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas, especially those arising from honeycomb lesions, have distinct pathological features.
研究特发性间质性肺炎（IIP）相关肺腺癌的病理特征。
对手术切除的与IIP相关的腺癌（IIP组）和无IIP的腺癌（非IIP组）进行分析。IIP组的腺癌分为两组：一组包括与蜂窝状病变中细支气管化生相关的肿瘤（H-IIP组），另一组包括与蜂窝状病变无关的肿瘤（NH-IIP组）。比较H-IIP组、NH-IIP组和非IIP组之间的组织形态学表现和免疫组化表达。H-IIP组的大多数肿瘤细胞呈高柱状，与近端支气管上皮具有相似特征，而NH-IIP组和非IIP组的肿瘤细胞呈棒状，与呼吸性细支气管/肺泡上皮具有相似特征。H-IIP组的腺癌倾向于甲状腺转录因子-1（TTF-1）阴性、肝细胞核因子-4α（HNF-4α）阳性。H-IIP组腺癌的表皮生长因子受体（EGFR）突变频率显著较低，尽管三组之间KRAS和间变性淋巴瘤激酶（ALK）突变频率无差异。
特发性间质性肺炎相关肺腺癌，尤其是起源于蜂窝状病变的腺癌，具有独特的病理特征。
