Winkler David A
CSIRO Manufacturing, Bag 10, Clayton South MDC 3169. Australia.
Curr Med Chem. 2017;24(5):483-496. doi: 10.2174/0929867323666161018141902.
Nanoparticles are finding many applications in medicine and other fields like photonics. Magnetic nanoparticles have additional advantages in medicine over non-magnetic hard nanoparticles, as their magnetic properties make them ideal for hyperthermic applications in therapy and for sensitive diagnostic imaging applications. I review the literature on computational models of the magnetic properties of nanoparticles specifically. Such models have the potential to accelerate the design of magnetic nanoparticles for medical applications. Much of the current literature relates to the modelling of magnetic nanoparticles for inducing hyperthermia in aberrant cells, with significant bodies of work aimed at simulating and predicting properties for medical imaging and targeted delivery of drugs and gene therapies.
纳米颗粒在医学和光子学等其他领域有许多应用。磁性纳米颗粒在医学上比非磁性硬纳米颗粒具有更多优势,因为它们的磁性使其非常适合用于治疗中的热疗应用以及敏感的诊断成像应用。我专门回顾了有关纳米颗粒磁性计算模型的文献。此类模型有可能加速用于医学应用的磁性纳米颗粒的设计。当前的许多文献都与用于在异常细胞中诱导热疗的磁性纳米颗粒建模有关,大量工作旨在模拟和预测用于医学成像以及药物和基因疗法靶向递送的特性。
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