Hallez Régis
Bacterial Cell cycle and Development (BCcD), unité de recherche en biologie des micro-organismes (URBM), université de Namur (UNamur), 61 rue de Bruxelles, 5000 Namur, Belgique.
Med Sci (Paris). 2016 Oct;32(10):843-848. doi: 10.1051/medsci/20163210017. Epub 2016 Oct 19.
To increase chances for a cell to survive in its natural environment, metabolism and cell cycle necessarily have to be interconnected. Indeed, cells need, on the one hand, to check their metabolic status before initiating a cell cycle step often energy-consuming, and, on the other hand, to complete some cell cycle steps before modifying their metabolism. Because bacteria do not differ from the rules, an increasing number of examples of connection between metabolism and cell cycle emerged these last years. Identifying metabolic enzymes as messengers coordinating metabolism and cell cycle allows the addition of another dimension to metabolic maps. Likewise, the very high conservation of these metabolic maps, from bacteria to human, allows inspiring research on tumor cells that are known to have an unrestrained cell cycle and a voracious appetite.
为了增加细胞在自然环境中存活的机会，新陈代谢和细胞周期必然相互关联。事实上，一方面，细胞在启动往往消耗能量的细胞周期步骤之前需要检查其代谢状态；另一方面，在改变新陈代谢之前需要完成一些细胞周期步骤。由于细菌也遵循这些规律，近年来出现了越来越多新陈代谢与细胞周期之间存在联系的例子。将代谢酶鉴定为协调新陈代谢和细胞周期的信使，为代谢图谱增添了另一个维度。同样，从细菌到人类，这些代谢图谱的高度保守性，有助于启发对已知具有不受控制的细胞周期和旺盛食欲的肿瘤细胞的研究。
