白塞氏眼病的结膜细胞学改变

Conjunctival Cytological Alterations in Ocular Behçet Disease.

作者信息

Demircan Elif, Citirik Mehmet, Berker Nilufer, Unverdi Hatice, Hucumenoglu Sema

机构信息

*Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey;†Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; and‡Department of Pathology, Ankara Training and Research Hospital, Ankara, Turkey.

出版信息

Cornea. 2016 Nov;35(11):1454-1458. doi: 10.1097/ICO.0000000000000909.

DOI:10.1097/ICO.0000000000000909

PMID:27760065

Abstract

PURPOSE

To evaluate the ocular surface alterations and tear film functions in patients with ocular Behçet disease (BD).

METHODS

This study included 48 eyes of 48 patients with inactive BD and a control group of 33 age- and sex-matched subjects. Schirmer I and tear break-up time (TBUT) tests were used to evaluate the tear film of the subjects. Impression cytology was used to evaluate morphological changes of the conjunctival surface epithelial cells.

RESULTS

The mean Schirmer I test result was 11.6 ± 5.9 mm/5 minutes and 16.1 ± 4.6 mm/5 minutes in the Behçet and control groups, respectively. The mean TBUT test result was 9.8 ± 5.6 seconds and 13.2 ± 5.7 seconds in the study and control groups, respectively. The Schirmer and TBUT test results were significantly lower in the study group than in the controls (P = 0.001 and P = 0.011, respectively). The mean impression cytology score was 1.3 ± 0.9 in the study group and significantly higher than the control group value of 0.4 ± 0.6 (P = 0.001).

CONCLUSIONS

Tear film functions and conjunctival surface epithelial morphology were significantly altered in patients with ocular BD.

摘要

目的

评估眼部白塞病（BD）患者的眼表改变和泪膜功能。

方法

本研究纳入48例非活动期BD患者的48只眼以及33名年龄和性别匹配的对照组受试者。采用Schirmer I试验和泪膜破裂时间（TBUT）试验评估受试者的泪膜。采用印迹细胞学评估结膜表面上皮细胞的形态变化。

结果

白塞病组和对照组的Schirmer I试验平均结果分别为11.6±5.9 mm/5分钟和16.1±4.6 mm/5分钟。研究组和对照组的TBUT试验平均结果分别为9.8±5.6秒和13.2±5.7秒。研究组的Schirmer试验和TBUT试验结果显著低于对照组（分别为P = 0.001和P = 0.011）。研究组的印迹细胞学平均评分为1.3±0.9，显著高于对照组的0.4±0.6（P = 0.001）。