保留幽门手术在全胰切除术联合胰岛自体移植中的临床疗效。
Clinical effectiveness of a pylorus-preserving procedure on total pancreatectomy with islet autotransplantation.
作者信息
Shahbazov Rauf, Yoshimatsu Gumpei, Haque Waqas Z, Khan Omar S, Saracino Giovanna, Lawrence Michael C, Kim Peter T, Onaca Nicholas, Naziruddin Bashoo, Levy Marlon F
机构信息
Department of Surgery, University of Virginia, Charlottesville, VA, USA.
Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA.
出版信息
Am J Surg. 2017 Jun;213(6):1065-1071. doi: 10.1016/j.amjsurg.2016.09.051. Epub 2016 Oct 8.
BACKGROUND
The impact of pylorus preserving procedures (PP) on total pancreatectomy with islet autotransplantation (TPIAT) has not been examined. This study aimed to investigate the clinical impact of the PP on TPIAT.
METHODS
The Baylor Simmons Transplant Institute database was queried to identify seventy-three patients who underwent TPIAT from 2006 to 2014. All patients were investigated in postoperative complications, long-term nutritional status, and graft function.
RESULTS
Patients with PP did not face worse outcomes in terms of delayed gastric emptying and length of hospital stay. Also, nutritional status and metabolic outcome, such as body weight, serum albumin level, serum vitamin level, HbA1c level, graft survival rate and insulin independent rate, were similar between both groups.
CONCLUSIONS
Clinical results including the graft function indicated that patients undergoing TPIAT with PP did not amplify surgical complications such as delayed gastric emptying and showed no significant advantage of nutrition and metabolic outcome.
背景
保留幽门手术（PP）对全胰切除联合胰岛自体移植（TPIAT）的影响尚未得到研究。本研究旨在探讨PP对TPIAT的临床影响。
方法
查询贝勒西蒙斯移植研究所数据库，以确定2006年至2014年期间接受TPIAT的73例患者。对所有患者的术后并发症、长期营养状况和移植物功能进行调查。
结果
PP患者在胃排空延迟和住院时间方面并未面临更差的结果。此外，两组患者的营养状况和代谢结果，如体重、血清白蛋白水平、血清维生素水平、糖化血红蛋白水平、移植物存活率和胰岛素非依赖率相似。
结论
包括移植物功能在内的临床结果表明，接受PP的TPIAT患者并未增加胃排空延迟等手术并发症，在营养和代谢结果方面也未显示出显著优势。
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