Ottewell Penelope D
Academic Unit of Clinical Oncology, Department of Oncology and Metabolism, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.
J Bone Oncol. 2016 Apr 13;5(3):124-127. doi: 10.1016/j.jbo.2016.03.007. eCollection 2016 Sep.
The primary role of osteoblasts is to lay down new bone during skeletal development and remodelling. Throughout this process osteoblasts directly interact with other cell types within bone, including osteocytes and haematopoietic stem cells. Osteoblastic cells also signal indirectly to bone-resorbing osteoclasts via the secretion of RANKL. Through these mechanisms, cells of the osteoblast lineage help retain the homeostatic balance between bone formation and bone resorption. When tumour cells disseminate in the bone microenvironment, they hijack these mechanisms, homing to osteoblasts and disrupting bone homeostasis. This review describes the role of osteoblasts in normal bone physiology, as well as interactions between tumour cells and osteoblasts during the processes of tumour cell homing to bone, colonisation of this metastatic site and development of overt bone metastases.
成骨细胞的主要作用是在骨骼发育和重塑过程中形成新骨。在这个过程中，成骨细胞直接与骨内的其他细胞类型相互作用，包括骨细胞和造血干细胞。成骨细胞还通过分泌RANKL间接向骨吸收破骨细胞发出信号。通过这些机制，成骨细胞谱系的细胞有助于维持骨形成和骨吸收之间的稳态平衡。当肿瘤细胞在骨微环境中扩散时，它们会劫持这些机制，归巢于成骨细胞并破坏骨稳态。这篇综述描述了成骨细胞在正常骨生理学中的作用，以及在肿瘤细胞归巢至骨、该转移部位的定植和明显骨转移发展过程中肿瘤细胞与成骨细胞之间的相互作用。
