使用CEST MRI和其他成像方法评估细胞外肿瘤微环境中的pH值。
Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods.
作者信息
Chen Liu Qi, Pagel Mark D
机构信息
Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA; Department of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA; Department of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
出版信息
Adv Radiol. 2015;2015. doi: 10.1155/2015/206405.
Tumor acidosis is a consequence of altered metabolism, which can lead to chemoresistance and can be a target of alkalinizing therapies. Noninvasive measurements of the extracellular pH (pHe) of the tumor microenvironment can improve diagnoses and treatment decisions. A variety of noninvasive imaging methods have been developed for measuring tumor pHe. This review provides a detailed description of the advantages and limitations of each method, providing many examples from previous research reports. A substantial emphasis is placed on methods that use MR spectroscopy and MR imaging, including recently developed methods that use chemical exchange saturation transfer MRI that combines some advantages of MR spectroscopy and imaging. Together, this review provides a comprehensive overview of methods for measuring tumor pHe, which may facilitate additional creative approaches in this research field.
肿瘤酸中毒是代谢改变的结果，可导致化疗耐药，并且可能成为碱化治疗的靶点。对肿瘤微环境细胞外pH值（pHe）进行无创测量可改善诊断和治疗决策。已经开发出多种用于测量肿瘤pHe的无创成像方法。本综述详细描述了每种方法的优缺点，并列举了许多以往研究报告中的实例。重点介绍了使用磁共振波谱和磁共振成像的方法，包括最近开发的利用化学交换饱和转移磁共振成像的方法，该方法结合了磁共振波谱和成像的一些优点。总之，本综述全面概述了测量肿瘤pHe的方法，这可能有助于该研究领域产生更多创新方法。
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