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肿瘤微环境与肿瘤源性小细胞外囊泡在癌症发展和治疗反应中的相互作用。

The interplay between the tumor microenvironment and tumor-derived small extracellular vesicles in cancer development and therapeutic response.

机构信息

The Affiliated Hospital, Southwest Medical University, Luzhou, PR China.

Department of Clinical Laboratory Medicine, the Affiliated Hospital, Southwest Medical University, Luzhou, PR China.

出版信息

Cancer Biol Ther. 2024 Dec 31;25(1):2356831. doi: 10.1080/15384047.2024.2356831. Epub 2024 May 20.

DOI:10.1080/15384047.2024.2356831
PMID:38767879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11110713/
Abstract

The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment. Extracellular vesicles (EVs) are small particles released by all cell types and often reflect the state of their parental cells and modulate other cells' functions through the various cargo they transport. Tumor-derived small EVs (TDSEVs) can transport specific proteins, nucleic acids and lipids tailored to propagate tumor signals and establish a favorable TME. Thus, the TME's biological characteristics can affect TDSEV heterogeneity, and this interplay can amplify tumor growth, dissemination, and resistance to therapy. This review discusses the interplay between TME and TDSEVs based on their biological characteristics and summarizes strategies for targeting cancer cells. Additionally, it reviews the current issues and challenges in this field to offer fresh insights into comprehending tumor development mechanisms and exploring innovative clinical applications.

摘要

肿瘤微环境（TME）通过深刻影响肿瘤细胞的增殖、转移、免疫逃逸和治疗耐药性，在肿瘤细胞存活中发挥着重要作用。细胞外囊泡（EVs）是所有细胞类型释放的小颗粒，通常反映其亲本细胞的状态，并通过它们运输的各种货物调节其他细胞的功能。肿瘤来源的小 EVs（TDSEVs）可以运输特定的蛋白质、核酸和脂质，专门传播肿瘤信号并建立有利的 TME。因此，TME 的生物学特征可以影响 TDSEV 的异质性，这种相互作用可以放大肿瘤的生长、扩散和对治疗的耐药性。本文根据其生物学特征讨论了 TME 与 TDSEVs 之间的相互作用，并总结了针对癌细胞的靶向策略。此外，还回顾了该领域当前存在的问题和挑战，为深入了解肿瘤发生机制和探索创新的临床应用提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/85b3ed49f2ff/KCBT_A_2356831_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/65279d942665/KCBT_A_2356831_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/622b64949d4f/KCBT_A_2356831_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/9b3847e3ad5a/KCBT_A_2356831_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/976b31de1ed4/KCBT_A_2356831_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/85b3ed49f2ff/KCBT_A_2356831_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/65279d942665/KCBT_A_2356831_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/622b64949d4f/KCBT_A_2356831_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/9b3847e3ad5a/KCBT_A_2356831_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/976b31de1ed4/KCBT_A_2356831_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b07/11110713/85b3ed49f2ff/KCBT_A_2356831_F0005_OC.jpg

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