Hautasaari Pekka, Savić Andrej M, Loberg Otto, Niskanen Eini, Kaprio Jaakko, Kujala Urho M, Tarkka Ina M
Department of Health Sciences, University of Jyväskylä, Rautpohjankatu 8, 40014, Jyväskylä, Finland.
School of Electrical Engineering, University of Belgrade, Belgrade, Serbia.
Brain Topogr. 2017 Jan;30(1):77-86. doi: 10.1007/s10548-016-0531-1. Epub 2016 Oct 19.
Associations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 ± 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images. We obtained exercise history and measured physical fitness and body composition. Equivalent electrical dipole sources of SMMR as well as gray matter (GM) voxel counts in regions of interest indicated by source analysis were evaluated. SMMR dipolar source strengths differed between active and inactive twins within twin pairs in postcentral gyrus, medial frontal gyrus and superior temporal gyrus and in anterior cingulate (AC) GM voxel counts differed similarly. Compared to active twins, their inactive twin brothers showed greater dipole strengths in short periods of the deviant-elicited SMMR and larger AC GM voxel counts. Stronger activation in early unattended cortical processing of the deviant sensory signals in inactive co-twins may imply less effective gating of somatosensory information in inactive twins compared to their active brothers. Present findings indicate that already in 30's long-term physical activity pattern is linked with specific brain indices, both in functional and structural domains.
长期体育活动与皮质功能和脑结构之间的关联尚不清楚。我们的目的是评估使用不一致的同卵男性双胞胎对设计是否能检测到与长期体育活动相关的脑功能和/或结构调节。精心挑选了九对同卵男性双胞胎，他们在休闲体育活动方面的配对内差异至少持续三年（平均年龄34±1岁）。我们记录了脑电图中对手指电刺激的体感失配反应（SMMR）以及全脑磁共振图像。我们获取了运动史并测量了身体素质和身体成分。评估了SMMR的等效电偶极源以及源分析指示的感兴趣区域中的灰质（GM）体素计数。在中央后回、额内侧回和颞上回中，双胞胎对中活跃和不活跃的双胞胎之间SMMR偶极源强度不同，前扣带回（AC）GM体素计数也有类似差异。与活跃的双胞胎相比，他们不活跃的双胞胎兄弟在异常诱发的SMMR的短时间内表现出更大的偶极强度和更大的AC GM体素计数。不活跃的双胞胎在早期对异常感觉信号的未被注意的皮质处理中更强的激活可能意味着与他们活跃的兄弟相比，不活跃的双胞胎在体感信息的门控方面效率较低。目前的研究结果表明，早在30多岁时，长期体育活动模式就与特定的脑指标在功能和结构领域都有关联。
