Abdel Rahman Mohamed F, Hashad Ingy M, Abou-Aisha Khaled, Abdel Maksoud Sahar M, Gad Mohamed Z
Biochemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Cairo, Egypt.
Clinical Biochemistry Unit, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, Egypt.
Clin Exp Pharmacol Physiol. 2017 Jan;44(1):132-134. doi: 10.1111/1440-1681.12684.
The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83±0.7 pg/mL) was significantly higher than controls (7.26±0.2 pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls.
本研究旨在评估埃及人群中内皮素（EDN）K198N单核苷酸多态性（SNP）、血清内皮素-1（ET-1）浓度与急性心肌梗死（AMI）之间的联系。研究队列包括84例急性心肌梗死发作患者和84例年龄匹配的健康对照者。分别通过测序和酶联免疫吸附测定（ELISA）确定内皮素基因型和浓度。急性心肌梗死患者与对照组之间的基因型分布无显著差异（P = 0.8341）。患者的血清ET-1平均浓度（13.83±0.7 pg/mL）显著高于对照组（7.26±0.2 pg/mL）（P<0.0001）。患者（P = 0.378）和对照组（P = 0.6164）中，不同EDN基因型的血清ET-1浓度无显著差异。因此，我们得出结论，在埃及人群中，EDN K198N基因型与ET-1浓度或早发性急性心肌梗死的发生率均无关。但是，急性心肌梗死患者的ET-1浓度高于对照组。
