一例登革出血热患者出现危及生命的血栓栓塞事件

Life-Threatening Thrombo-embolic Events in a Case of Dengue Hemorrhagic Fever.

作者信息

Agarwal Arun, Sharma Samiksha, Airun Mala

机构信息

Senior Consultant and Head, Department of Internal Medicine.

Consultant and Head, Department of Pathology.

出版信息

J Assoc Physicians India. 2016 Aug;64(8):87-89.

PMID:27762119

Abstract

In Dengue Hemorrhagic Fever (DHF), hemorrhagic manifestations are common but thrombotic events are uncommonly reported, despite the wide range of increased procoagulant activity during Dengue Fever illness. We report a case of a 55-year-old man of Asian Indian ethnicity who developed large vein thrombotic event -Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) in the acute phase of DHF. His condition was further complicated by associated thrombocytopenia. The etiological connections between dengue viral infection with thrombocytopenia, DVT/PE and abnormal thrombophilia profile as well as the treatment dilemmas posed in treating a patient of DF with hemorrhagic manifestations and associated DVT/PE, and the role of eltrombopag are discussed.

摘要

在登革出血热（DHF）中，出血表现很常见，但血栓形成事件的报道却很少见，尽管在登革热疾病期间促凝活性广泛增加。我们报告一例55岁的亚洲印度裔男性，他在DHF急性期发生了大静脉血栓形成事件——深静脉血栓形成（DVT）和肺栓塞（PE）。他的病情因合并血小板减少症而进一步复杂化。本文讨论了登革病毒感染与血小板减少症、DVT/PE和异常血栓形成倾向之间的病因联系，以及治疗有出血表现并合并DVT/PE的登革热患者时所面临的治疗困境，以及艾曲泊帕的作用。