前列腺素对丹参中分离出的丹酚酸B所致肾脏反应的作用。

Contribution of prostaglandins to the renal responses to magnesium lithospermate B isolated from salviae miltiorrhizae radix.

作者信息

Yokozawa T, Chung H Y, Lee T W, Oura H, Tanaka T, Nonaka G, Nishioka I, Hirai A

出版信息

Chem Pharm Bull (Tokyo). 1989 Jun;37(6):1568-71. doi: 10.1248/cpb.37.1568.

DOI:10.1248/cpb.37.1568

Abstract

The involvement of prostanoids in the improvement of adenine-induced renal failure in rats by magnesium lithospermate B was studied. After intraperitoneal administration of magnesium lithospermate B to renal failure rats, the levels of glomerular filtration rate, renal plasma flow and renal blood flow were increased. Urinary excretions of prostaglandin E2 (PGE2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in renal failure rats were increased by the administration of magnesium lithospermate B, while that of thromboxane B2 had no effect. Pretreatment with indomethacin abolished the improving effect of magnesium lithospermate B on renal function concomitantly with markedly suppressed urinary excretion of prostanoids. These results suggest that the increased formation of PGE2 and 6-keto-PGF1 alpha might contribute to the improvement of adenine-induced renal failure in rats by magnesium lithospermate B.

摘要

研究了前列腺素类物质在丹酚酸B镁改善腺嘌呤诱导的大鼠肾衰竭中的作用。给肾衰竭大鼠腹腔注射丹酚酸B镁后，肾小球滤过率、肾血浆流量和肾血流量水平升高。丹酚酸B镁给药可使肾衰竭大鼠尿中前列腺素E2（PGE2）和6-酮-前列腺素F1α（6-酮-PGF1α）的排泄增加，而对血栓素B2则无影响。吲哚美辛预处理消除了丹酚酸B镁对肾功能的改善作用，同时显著抑制了前列腺素类物质的尿排泄。这些结果表明，PGE2和6-酮-PGF1α生成增加可能有助于丹酚酸B镁改善腺嘌呤诱导的大鼠肾衰竭。