紫草酸镁对肾脏中激肽 - 前列腺素E2系统的促进作用。
The promoting action of magnesium lithospermate B on the kinin-prostaglandin E2 system in the kidney.
作者信息
Chung H Y, Kim J S, Chung H Y, Yokozawa T, Oura H
机构信息
College of Pharmacy, Pusan National University, Gum Jung-Ku, Korea.
出版信息
Pharmacol Toxicol. 1995 Apr;76(4):240-4. doi: 10.1111/j.1600-0773.1995.tb00136.x.
The effect of magnesium lithospermate B purified from Salviae Miltiorrhizae Radix on the kinin-prostaglandin E2 system was investigated using kidney slices and isolated kidney microsomes. Magnesium lithospermate B markedly increased the amount of thiobarbituric acid-reactive substances produced by incubation of arachidonic acid in renal slices. Enhancement of arachidonic acid-mediated oxygenation of 1,3-diphenylisobenzofuran was also observed in renal microsomes from rats treated with magnesium lithospermate B, indicating an increase of prostaglandin biosynthesis. Furthermore, magnesium lithospermate B significantly increased the synthesis of prostaglandin E2 in renal slices, but the magnesium lithospermate B-mediated response was blunted with kinin antagonist. On the basis of the above results, it is apparent that magnesium lithospermate B exerts an influence on the prostaglandin system via kinin receptors.
利用肾切片和分离的肾微粒体，研究了从丹参中纯化得到的丹酚酸B镁对激肽-前列腺素E2系统的影响。丹酚酸B镁显著增加了肾切片中花生四烯酸孵育产生的硫代巴比妥酸反应性物质的量。在用丹酚酸B镁处理的大鼠的肾微粒体中，也观察到花生四烯酸介导的1,3-二苯基异苯并呋喃氧化增强，表明前列腺素生物合成增加。此外，丹酚酸B镁显著增加了肾切片中前列腺素E2的合成，但丹酚酸B镁介导的反应被激肽拮抗剂减弱。基于上述结果，很明显丹酚酸B镁通过激肽受体对前列腺素系统产生影响。
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