Lim Ming-Sheng, Wang Jiang Huai, Power Derek G, Redmond H Paul
Departments of aAcademic Surgery bMedical Oncology, University College Cork, Cork University Hospital, Cork, Ireland.
Melanoma Res. 2017 Feb;27(1):1-7. doi: 10.1097/CMR.0000000000000303.
The link between inflammation, immunity and cancer is well established. In the last decade, there has been considerable excitement over cancer stem cells, believed to be a subset of tumour cells responsible for their initiation, propagation and resistance to conventional chemoradiotherapy. In this review, we discuss the characterization of cancer stem cells and describe their modulation by inflammation with a focus on melanoma.
炎症、免疫与癌症之间的联系已得到充分证实。在过去十年中，癌症干细胞引发了广泛关注，人们认为它是肿瘤细胞的一个亚群，与肿瘤的起始、增殖以及对传统放化疗的抗性有关。在这篇综述中，我们讨论了癌症干细胞的特征，并描述了炎症对其的调节作用，重点关注黑色素瘤。
