Bourne D W
College of Pharmacy, University of Oklahoma, Oklahoma City 73190.
Comput Methods Programs Biomed. 1989 Jul;29(3):191-5. doi: 10.1016/0169-2607(89)90129-6.
BOOMER is an improved version of an earlier non-linear regression program, MULTI-FORTE. Rather than the user writing a FORTRAN subroutine, models are defined by means of the parameters which make up the model. Models based on differential equations are specified by means of zero-order, first-order, or Michaelis-Menten-type rate constants. Doses (in units of mass) are translated into the usually observed concentration units by a reciprocal volume parameter. Integrated equation models are specified in terms of baseline terms, exponential terms, or the emax function with slope term as described by the Hill equation. Time points can be specified as parameters to specify dose times, infusion start/stop times, or lag times. With careful selection of parameters quite complex models can be specified. The user has a choice of differential equation solvers and fitting algorithms.
BOOMER是早期非线性回归程序MULTI - FORTE的改进版本。与用户编写FORTRAN子程序不同，模型是通过构成模型的参数来定义的。基于微分方程的模型通过零阶、一阶或米氏类型的速率常数来指定。剂量（以质量单位）通过倒数体积参数转换为通常观察到的浓度单位。积分方程模型根据基线项、指数项或如希尔方程所描述的带有斜率项的最大效应（emax）函数来指定。时间点可以指定为参数，以指定给药时间、输注开始/停止时间或滞后时间。通过仔细选择参数，可以指定相当复杂的模型。用户可以选择微分方程求解器和拟合算法。
