tau 磷酸化——远不止是一个生物标志物。
Tau Phosphorylation-Much More than a Biomarker.
机构信息
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
出版信息
Neuron. 2016 Oct 19;92(2):265-267. doi: 10.1016/j.neuron.2016.10.011.
Lasagna-Reeves et al. (2016) demonstrate that preventing the kinase Nuak1 from phosphorylating the microtubule-associated protein tau reduces the level of potentially pathogenic tau species in brain, a novel therapeutic strategy that could help counteract Alzheimer's disease and several other neurological disorders.
拉沙尼-里夫斯等人（2016 年）证明，阻止激酶 Nuak1 使微管相关蛋白 tau 磷酸化，可以降低脑中潜在致病 tau 种类的水平，这是一种新的治疗策略，可能有助于对抗阿尔茨海默病和其他几种神经退行性疾病。
Zotero 插件