You X Y
Zhonghua Wai Ke Za Zhi. 1989 Mar;27(3):141-3, 187-8.
Secretory immunoglobulin A (SIgA) in the bile was measured in 71 patients with cholelithiasis and in a control group of 10 patients without hepatobiliary disease, by using enzyme immunoassay specific to SIgA. Bile SIgA levels of patients with pigment stone, positive culture of bile for bacteria in a all of them, were significantly lower than that in control group (P less than 0.005); constituent ratios of SIgA in total immunoglobulins were markedly lower than that in the control (P less than 0.001); relative coefficient of excretion of SIgA was also significantly lower than that in the control (P less than 0.001). In patients with infectious cholecystolithiasis, bile SIgA concentrations were lower than that without infection (P less than 0.01), and that in the control (P less than 0.01). These results suggest that there is certain relation between biliary tract infection and low concentrations of bile SIgA.
采用针对分泌型免疫球蛋白A（SIgA）的酶免疫测定法，对71例胆石症患者及10例无肝胆疾病的对照组患者的胆汁中SIgA进行了检测。色素结石患者胆汁SIgA水平均显著低于对照组（P<0.005），且所有患者胆汁细菌培养均为阳性；其总免疫球蛋白中SIgA的构成比明显低于对照组（P<0.001）；SIgA排泄相对系数也显著低于对照组（P<0.001）。感染性胆囊结石患者胆汁SIgA浓度低于未感染者（P<0.01）及对照组（P<0.01）。这些结果提示，胆道感染与胆汁SIgA低浓度之间存在一定关系。
