Zhou Zu-Mu, Xu Yi, Hu Cai-Song, Pan Qiong-Jiao, Wei Jing-Jiao
Department of Emergency Response, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
Department of infectious disease control and prevention, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
J Trop Pediatr. 2017 Jun 1;63(3):182-188. doi: 10.1093/tropej/fmw070.
This study aimed to analyze the epidemiological characteristics of hand, foot and mouth disease (HFMD) during 2008-14 in Wenzhou, China. The epidemiological data of HFMD retrieved from the Wenzhou Center for Disease Control and Prevention were retrospectively analyzed. HFMD infections with enterovirus 71 (EV71), Cox A16 or other pathogens were further verified by polymerase chain reaction (PCR) and real-time PCR. A total of 213 617 cases of HFMD were reported between 2008 and 2014 in Wenzhou. The average incidence was 384.31 of 100 000, and the fatality rate was 0.14‰. The incidence of HFMD peaked between April and July, and it occurred more frequently in males than in females. Approximately 92.68% of the HFMD patients were children aged <5 years. Nearly 80% of the cases were diagnosed within 2 days after onset. The major HFMD pathogen was EV71. This study suggested that appropriate comprehensive prevention and control measures should be taken to avoid the spread of HFMD.
本研究旨在分析2008 - 2014年中国温州手足口病（HFMD）的流行病学特征。对从温州市疾病预防控制中心获取的手足口病流行病学数据进行回顾性分析。采用聚合酶链反应（PCR）和实时荧光定量PCR进一步鉴定肠道病毒71型（EV71）、柯萨奇病毒A16型（Cox A16）或其他病原体引起的手足口病感染。2008年至2014年温州共报告手足口病病例213617例。平均发病率为十万分之384.31，病死率为0.14‰。手足口病发病率在4月至7月达到高峰，男性发病较女性更为频繁。约92.68%的手足口病患者为5岁以下儿童。近80%的病例在发病后2天内确诊。手足口病的主要病原体为EV71。本研究表明，应采取适当的综合防控措施以避免手足口病传播。
