Szablewski Leszek, Sulima Anna
Biol Chem. 2017 Apr 1;398(4):411-423. doi: 10.1515/hsz-2016-0196.
It is known fact that diabetes mellitus (DM) affects blood cells. Changes in the erythrocyte membrane, disorder in hemoglobin oxygen-binding and modification in mechanical characteristics, are effects of hyperglycemia on red blood cells. Altered susceptibility infection of patients with diabetes has been ascribed to a depression in the function of polymorphonuclear leukocytes. Neutrophil function in patients with diabetes with good glucose control is slightly different than in healthy ones. DM causes significant changes in lymphocytes metabolism and their functions. Patients with diabetes, presenting with acute coronary syndrome, are at higher risk of cardiovascular complications and recurrent ischemic events in comparison to non-diabetic counterparts. Various mechanisms, including endothelial dysfunction, platelet hyperactivity, and abnormalities in coagulation and fibrynolysis have been implicated for this increased atherothrombotic risk. There are many other alterations of blood cells due to DM. In the present review we focused on modifications of blood cells due to DM. Then, as a second point, we explored how the changes affect functions of red blood cells, white blood cells and platelets.
糖尿病（DM）会影响血细胞，这是一个众所周知的事实。红细胞膜的变化、血红蛋白氧结合紊乱以及机械特性的改变，都是高血糖对红细胞产生的影响。糖尿病患者感染易感性的改变被归因于多形核白细胞功能的抑制。血糖控制良好的糖尿病患者的中性粒细胞功能与健康人略有不同。糖尿病会导致淋巴细胞代谢及其功能发生显著变化。与非糖尿病患者相比，患有急性冠状动脉综合征的糖尿病患者发生心血管并发症和复发性缺血事件的风险更高。各种机制，包括内皮功能障碍、血小板活性过高以及凝血和纤维蛋白溶解异常，都与这种动脉粥样硬化血栓形成风险增加有关。糖尿病还会导致血细胞发生许多其他改变。在本综述中，我们重点关注了糖尿病引起的血细胞变化。其次，我们探讨了这些变化如何影响红细胞、白细胞和血小板的功能。
