铁蛋白中铁氧化酶中心的鉴定。
Identification of the ferroxidase centre in ferritin.
作者信息
Lawson D M, Treffry A, Artymiuk P J, Harrison P M, Yewdall S J, Luzzago A, Cesareni G, Levi S, Arosio P
机构信息
Krebs Institute, Department of Molecular Biology and Biotechnology, The University, Sheffield, England.
出版信息
FEBS Lett. 1989 Aug 28;254(1-2):207-10. doi: 10.1016/0014-5793(89)81040-3.
PMID:2776883
Abstract
Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.
摘要
借助定点诱变技术对人重链铁蛋白中的亚铁氧化酶活性进行了研究。通过X射线晶体学发现的一个位点现已被确定为亚铁氧化酶中心。该中心仅存在于重链中，位于链折叠的四螺旋束内。
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