Damewood M D, Shen W, Zacur H A, Schlaff W D, Rock J A, Wallach E E
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Fertil Steril. 1989 Sep;52(3):398-400. doi: 10.1016/s0015-0282(16)60906-8.
Concentrations of human chorionic gonadotropin (hCG) were measured after intramuscular hCG administration in 34 patients undergoing ovarian stimulation in an in vitro fertilization program. Serum hCG levels were detectable by an immunoenzymetric assay up to 14 days after injection. Individual variation in hCG concentration after injection could be minimized by expressing the daily hCG level as a fractional distribution of the value observed 36 hours after hCG administration (hCG0). In nonpregnant patients, less than 10% of the hCG0 value was found on day 10. The disappearance rate measured 36 hours after injection of hCG was exponential with a mean half-life of 2.32 days. These findings are significant for ovarian stimulation protocols, including exogenous hCG, with respect to timing and accuracy of quantitative pregnancy testing.
在一项体外受精计划中，对34名接受卵巢刺激的患者进行肌肉注射人绒毛膜促性腺激素（hCG）后，测量了hCG的浓度。通过免疫酶测定法在注射后长达14天可检测到血清hCG水平。通过将每日hCG水平表示为hCG给药后36小时观察值的分数分布（hCG0），可将注射后hCG浓度的个体差异降至最低。在未怀孕的患者中，在第10天发现的hCG0值不到10%。注射hCG后36小时测得的消失率呈指数形式，平均半衰期为2.32天。这些发现对于包括外源性hCG在内的卵巢刺激方案在定量妊娠试验的时间和准确性方面具有重要意义。
