Chu Xu, Liu Xiao-Ju, Qiu Jing-Man, Zeng Xiao-Li, Bao Hai-Rong, Shu Juan
Department of Gerontal Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Department of Gerontal Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Environ Toxicol Pharmacol. 2016 Dec;48:76-84. doi: 10.1016/j.etap.2016.10.006. Epub 2016 Oct 14.
Astragalus and Codonopsis pilosula are used for their immunomodulatory and anti-inflammatory effects. Here, we investigated the effects of Astragalus polysaccharides (APS) and Codonopsis pilosula polysaccharides (CPP) on alveolar macrophage (AM) phagocytosis and inflammation in chronic obstructive pulmonary disease (COPD) associated with exposure to particulate matter with a mean aerodynamic diameter ≤2.5μm (PM2.5). A mouse model of COPD was established by cigarette smoke exposure. PM2.5 exposure was performed by inhalation of a PM2.5 solution aerosol. APS and CPP were administered intragastrically. COPD showed defective AM phagocytosis and increased levels of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage fluid and serum. PM2.5 exposure aggravated the damage, and this effect was reversed by APS and CPP gavage. The results indicate that APS and CPP may promote defective AM phagocytosis and ameliorate the inflammatory response in COPD with or without PM2.5 exposure.
黄芪和党参因其免疫调节和抗炎作用而被使用。在此，我们研究了黄芪多糖（APS）和党参多糖（CPP）对与暴露于平均空气动力学直径≤2.5μm的颗粒物（PM2.5）相关的慢性阻塞性肺疾病（COPD）中肺泡巨噬细胞（AM）吞噬作用和炎症的影响。通过香烟烟雾暴露建立COPD小鼠模型。通过吸入PM2.5溶液气雾剂进行PM2.5暴露。APS和CPP通过胃内给药。COPD表现为AM吞噬作用缺陷，支气管肺泡灌洗液和血清中白细胞介素（IL）-6、IL-8和肿瘤坏死因子（TNF）-α水平升高。PM2.5暴露加剧了损伤，而这种作用通过APS和CPP灌胃得以逆转。结果表明，APS和CPP可能促进COPD中缺陷的AM吞噬作用，并改善有或无PM2.5暴露情况下的炎症反应。
