Darne F J, McGarrigle H H, Lachelin G C
University College and Middlesex School of Medicine, London, U.K.
Eur J Obstet Gynecol Reprod Biol. 1989 Aug;32(2):57-66. doi: 10.1016/0028-2243(89)90184-6.
The diurnal variation of plasma oestrone (E1), oestradiol (E2), oestriol (E3), progesterone (P), cortisol (F) and dehydroepiandrosterone sulphate (DHAS) and saliva E1, E2, E3, P and F was investigated in matched plasma, and saliva samples were obtained hourly from 08.00 to 24.00 h and at 04.00, 07.00 and 08.00 h from nine pregnant women (3 at 30, 3 at 34 and 3 at 38 weeks gestation). A diurnal variation in plasma and saliva cortisol levels was found in all subjects and in plasma DHAS in 8 out of 9 subjects. No consistent diurnal variation was found at any gestation in any of the other hormones in plasma or saliva. There was a significant correlation between saliva E3 and P levels at 30 weeks gestation but no other consistent correlations between hormone levels were found at any gestation.
研究了9名孕妇（妊娠30周、34周和38周各3名）血浆雌酮（E1）、雌二醇（E2）、雌三醇（E3）、孕酮（P）、皮质醇（F）和硫酸脱氢表雄酮（DHAS）以及唾液E1、E2、E3、P和F的昼夜变化。从08:00至24:00每小时采集一次血浆和唾液样本，并在04:00、07:00和08:00采集样本。所有受试者的血浆和唾液皮质醇水平均呈现昼夜变化，9名受试者中有8名的血浆DHAS呈现昼夜变化。在任何孕周，血浆或唾液中的其他任何激素均未发现一致的昼夜变化。妊娠30周时，唾液E3和P水平之间存在显著相关性，但在任何孕周均未发现激素水平之间的其他一致相关性。
