治疗参与度可调节神经认知障碍对接受治疗的HIV感染吸毒者抗逆转录病毒治疗依从性的影响。
Treatment Engagement Moderates the Effect of Neurocognitive Impairment on Antiretroviral Therapy Adherence in HIV-Infected Drug Users in Treatment.
作者信息
Shrestha Roman, Karki Pramila, Huedo-Medina Tania B, Copenhaver Michael
出版信息
J Assoc Nurses AIDS Care. 2017 Jan-Feb;28(1):85-94. doi: 10.1016/j.jana.2016.09.007. Epub 2016 Sep 22.
Abstract
Neurocognitive impairment (NCI) and treatment engagement (TE) have been shown to significantly predict antiretroviral therapy (ART) adherence, but no studies have explored the ways and the extent to which similar outcomes might occur when these factors operate together, particularly for people who use drugs (PWUDs). We sought to discover whether TE moderated the effect of NCI on adherence to ART in HIV-infected individuals. One hundred sixteen HIV-infected, methadone-maintained people who reported HIV risk behaviors were enrolled in the study. Variables of interest (NCI, ART adherence, TE) were assessed using audio computer-assisted self-interview. Results revealed a significant interactive effect of NCI and TE on ART adherence, which supported the moderation effect. Findings from post hoc analyses showed that NCI was negatively associated with adherence to ART at low levels of TE. Findings suggest the need to accommodate individual NCI and improve TE as a means to enhance ART adherence in HIV-infected PWUDs.
摘要
神经认知障碍（NCI）和治疗参与度（TE）已被证明能显著预测抗逆转录病毒疗法（ART）的依从性，但尚无研究探讨当这些因素共同作用时，类似结果可能出现的方式和程度，尤其是对于吸毒者（PWUDs）。我们试图发现TE是否会调节NCI对HIV感染者ART依从性的影响。116名报告有HIV风险行为、感染HIV且接受美沙酮维持治疗的人参与了这项研究。使用音频计算机辅助自我访谈评估了相关变量（NCI、ART依从性、TE）。结果显示NCI和TE对ART依从性有显著的交互作用，这支持了调节作用。事后分析结果表明，在低水平的TE时，NCI与ART依从性呈负相关。研究结果表明，需要考虑个体的NCI情况并提高TE，以此作为增强HIV感染的PWUDs的ART依从性的一种手段。
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