Liang Xingqun, Evans Sylvia M, Sun Yunfu
Key Laboratory of Arrhythmia, Shanghai East Hospital, Ministry of Education, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr. M/C 0613C, BSB 5027, La Jolla, CA, 92093, USA.
Cell Mol Life Sci. 2017 Apr;74(7):1247-1259. doi: 10.1007/s00018-016-2400-1. Epub 2016 Oct 21.
The sinoatrial node (SAN) is the dominant pacemaker of the heart. Abnormalities in SAN formation and function can cause sinus arrhythmia, including sick sinus syndrome and sudden death. A better understanding of genes and signaling pathways that regulate SAN development and function is essential to develop more effective treatment to sinus arrhythmia, including biological pacemakers. In this review, we briefly summarize the key processes of SAN morphogenesis during development, and focus on the transcriptional network that drives SAN development.
窦房结（SAN）是心脏的主要起搏点。窦房结形成和功能异常可导致窦性心律失常，包括病态窦房结综合征和猝死。更好地了解调节窦房结发育和功能的基因和信号通路对于开发更有效的窦性心律失常治疗方法（包括生物起搏器）至关重要。在这篇综述中，我们简要总结了发育过程中窦房结形态发生的关键过程，并重点关注驱动窦房结发育的转录网络。
