用于新生儿肺部疾病的细胞疗法。
Cell-based therapies for neonatal lung disease.
作者信息
O'Reilly Megan, Thébaud Bernard
机构信息
Department of Physiology and Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1.
Sinclair Centre for Regenerative Medicine and Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, K1H 8L6.
出版信息
Cell Tissue Res. 2017 Mar;367(3):737-745. doi: 10.1007/s00441-016-2517-4. Epub 2016 Oct 22.
Preterm birth occurs in approximately 11 % of all births worldwide. Advances in perinatal care have enabled the survival of preterm infants born as early as 23-24 weeks of gestation. However, many are affected by bronchopulmonary dysplasia (BPD)-a common respiratory complication of preterm birth, which has life-long consequences for lung health. Currently, there is no specific treatment for BPD. Recent advances in stem cell research have opened new therapeutic avenues for prevention/repair of lung damage. This review summarizes recent pre-clinical data and early clinical translation of cell-based therapies for BPD.
全球约11%的分娩为早产。围产期护理的进步使妊娠23 - 24周出生的早产儿得以存活。然而，许多早产儿受支气管肺发育不良（BPD）影响，这是早产常见的呼吸系统并发症，会对肺部健康产生终身影响。目前，BPD尚无特效治疗方法。干细胞研究的最新进展为预防/修复肺损伤开辟了新的治疗途径。本综述总结了近期关于BPD细胞疗法的临床前数据和早期临床转化情况。
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