Li Shurong, Fu Shufang, Xiao Yichen, Xu Gaosi
Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
Medical Center of the Graduate School, Nanchang University, Nanchang, People's Republic of China.
Am J Cardiovasc Drugs. 2017 Feb;17(1):17-25. doi: 10.1007/s40256-016-0194-z.
Acute kidney injury (AKI) is a common and severe complication of cardiac surgery, and related rates of both hospitalization and long-term mortality are increasing. A number of studies have explored the preventive effects of perioperative pharmacological therapy on AKI after cardiac surgery. However, the mechanisms of AKI are multifaceted, and no universal treatment has been confirmed as beneficial. We review and analyze several current perioperative pharmacological therapies for AKI after cardiac surgery to identify promising preventive strategies.
急性肾损伤(AKI)是心脏手术常见且严重的并发症,住院率和长期死亡率均呈上升趋势。多项研究探讨了围手术期药物治疗对心脏手术后AKI的预防作用。然而,AKI的发病机制是多方面的,尚未证实有普遍有效的治疗方法。我们回顾并分析了目前几种用于心脏手术后AKI的围手术期药物治疗方法,以确定有前景的预防策略。