Vanicek Thomas, Kutzelnigg Alexandra, Philippe Cecile, Sigurdardottir Helen L, James Gregory M, Hahn Andreas, Kranz Georg S, Höflich Anna, Kautzky Alexander, Traub-Weidinger Tatjana, Hacker Marcus, Wadsak Wolfgang, Mitterhauser Markus, Kasper Siegfried, Lanzenberger Rupert
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria.
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Austria.
Hum Brain Mapp. 2017 Feb;38(2):792-802. doi: 10.1002/hbm.23418. Epub 2016 Oct 22.
Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BP ) in patients with ADHD and to assess associations of SERT BP between the brain regions. 25 medication-free patients with ADHD (age ± SD; 32.39 ± 10.15; 10 females) without any psychiatric comorbidity and 25 age and sex matched healthy control subjects (33.74 ± 10.20) were measured once with PET and the highly selective and specific radioligand [ C]DASB. SERT BP maps in nine a priori defined ROIs exhibiting high SERT binding were compared between groups by means of a linear mixed model. Finally, adopted from structural and functional connectivity analyses, we performed correlational analyses using regional SERT binding potentials to examine molecular interregional associations between all selected ROIs. We observed significant differences in the interregional correlations between the precuneus and the hippocampus in patients with ADHD compared to healthy controls, using SERT BP of the investigated ROIs (P < 0.05; Bonferroni corrected). When correlating SERT BP and age in the ADHD and the healthy control group, we confirmed an age-related decline in brain SERT binding in the thalamus and insula (R = 0.284, R = 0.167, Ps < 0.05; Bonferroni corrected). The results show significantly different interregional molecular associations of the SERT expression for the precuneus with hippocampus in patients with ADHD, indicating presumably altered functional coupling. Altered interregional coupling between brain regions might be a sensitive approach to demonstrate functional and molecular alterations in psychiatric conditions. Hum Brain Mapp 38:792-802, 2017. © 2016 Wiley Periodicals, Inc.
已发现血清素能神经传递改变会导致冲动和攻击行为，以及运动活动增加，所有这些都是注意力缺陷多动障碍（ADHD）的关键症状。这项正电子发射断层扫描（PET）研究的主要目的是调查ADHD患者的血清素转运体结合潜能（SERT BP），并评估脑区之间SERT BP的相关性。对25名未服用药物的ADHD患者（年龄±标准差；32.39±10.15；10名女性）进行了测量，这些患者无任何精神疾病合并症，同时选取25名年龄和性别匹配的健康对照者（33.74±10.20），使用高选择性和特异性放射性配体[C]DASB对他们进行了一次PET测量。通过线性混合模型比较了两组在9个预先定义的显示高SERT结合的感兴趣区域（ROI）中的SERT BP图谱。最后，借鉴结构和功能连接性分析，我们使用区域SERT结合潜能进行相关性分析，以检查所有选定ROI之间的分子区域间关联。使用所研究ROI的SERT BP，我们观察到与健康对照相比，ADHD患者楔前叶和海马体之间的区域间相关性存在显著差异（P<0.05；Bonferroni校正）。当将ADHD组和健康对照组的SERT BP与年龄进行相关性分析时，我们证实丘脑和脑岛中脑SERT结合存在与年龄相关的下降（R=0.284，R=0.167，P<0.05；Bonferroni校正）。结果显示，ADHD患者楔前叶与海马体的SERT表达区域间分子关联存在显著差异，这可能表明功能耦合发生了改变。脑区之间区域间耦合的改变可能是一种敏感的方法，用于证明精神疾病中的功能和分子改变。《人类大脑图谱》38:792 - 802，2017年。©2016威利期刊公司
