Tsintsadze I, Gorgoshadze T, Donskov S, Akhvlediani L, Nagervadze M
Batumi Shota Rustaveli State University, Faculty of Natural Sciences and Health Care, Department of Biology, Georgia.
Georgian Med News. 2016 Sep(258):54-59.
The distribution of erythrocyte blood group antigens was evaluated among 656 donors; samples were provided by the diagnostic laboratory "Medina" Ltd Health Centre of Batumi. Lab analysis of the sample was conducted by the immunogenetics laboratory at Batumi Shota Rustaveli State University. The frequency of the ABO allele system in donors was as follows: r (0.70), q (0.23), p (0.07). The distribution of Rhesus (Rh) factor in the donor population was as follows: Rh(-) was found among 16.3±1.43% of investigated donors; the Rh(+) phenotype was found in 83.7±1.43% of donors. Additionally, the CcDee phenotype frequency was 29.9±1.78%; CCD-ee was 17.2±1.47%; ccddee was 14.9±1.38%; and CcD-Ee was 13.9±1.34%; ccD-Ee phenotype was 11.1±1.22%; ccD-ee was 5.5±0.88%; same phenotype indicators -2.1±0.55 were observed for CcD-EE and ccD-EE; CCD-Ee was 1.4±0.45%, CCD-EE was 0.4±0.26%; and finally, the frequency of Ccddee phenotype amounts was 1.1±0.40%, ccddEe and CCddee phenotypes were both 0.2±0.17%. The analysis of the Kell system allele revealed a low frequency for the p allele at 0.05, whereas the frequency of the q allele was 0.95. This large epidemiologic analysis of donor blood provides valuable information for hematological and transfusion centers to inform the preparation of blood components for transfusion.
对656名献血者的红细胞血型抗原分布情况进行了评估;样本由巴统“麦地那”有限公司健康中心诊断实验室提供。样本的实验室分析由巴统绍塔·鲁斯塔维利国立大学免疫遗传学实验室进行。献血者中ABO等位基因系统的频率如下:r(0.70)、q(0.23)、p(0.07)。献血人群中恒河猴(Rh)因子的分布如下:在16.3±1.43%的受调查献血者中发现Rh(-);在83.7±1.43%的献血者中发现Rh(+)表型。此外,CcDee表型频率为29.9±1.78%;CCD-ee为17.2±1.47%;ccddee为14.9±1.38%;CcD-Ee为13.9±1.34%;ccD-Ee表型为11.1±1.22%;ccD-ee为5.5±0.88%;CcD-EE和ccD-EE的相同表型指标为-2.1±0.55;CCD-Ee为1.4±0.45%,CCD-EE为0.4±0.26%;最后,Ccddee表型频率为1.1±0.40%,ccddEe和CCddee表型均为0.2±0.17%。凯尔系统等位基因分析显示p等位基因频率较低,为0.05,而q等位基因频率为0.95。这项对献血者血液的大型流行病学分析为血液学和输血中心提供了有价值的信息,以便为输血准备血液成分提供参考。