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美沙酮治疗期间自我报告犯罪和监禁率下降:从丁丙诺啡转为美沙酮和维持治疗新使用者的患者比较(ANRS-Methaville 试验)。

Decrease in self-reported offences and incarceration rates during methadone treatment: A comparison between patients switching from buprenorphine to methadone and maintenance treatment incident users (ANRS-Methaville trial).

机构信息

INSERM U912 (SESSTIM), Marseille, France; Université Aix Marseille, IRD, UMR-S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.

INSERM, Research Unit 669, Paris, France; Université Paris-Sud and Université Paris Descartes, UMR-S0669, Paris, France; Centre Pierre Nicole, Paris, France.

出版信息

Int J Drug Policy. 2017 Jan;39:86-91. doi: 10.1016/j.drugpo.2016.08.005. Epub 2016 Oct 19.

Abstract

BACKGROUND

Patients receiving buprenorphine who are poor responders can continue to commit drug-related offences. Switching them from buprenorphine to methadone may result in reduced criminal behaviour. We compared self-reported offences and incarceration before and after starting methadone treatment of patients switching from buprenorphine (PSB) and maintenance treatment incident users (MIU).

METHODS

Data on offences, incarceration and other information, were obtained via a telephone interview. Mixed models were used to assess the impact of methadone initiation and being PSB or MIU on (1) the number of days when offences were committed (drug sale, drug purchase, other offences) and (2) experiencing incarceration during the previous 6 months.

RESULTS

Among the 176 patients with at least one assessment for self-reported offences, 51.7% were PSB. Receiving methadone was significantly associated with a reduction in the number of days when drug sale or drug purchase offences were committed, but not other offences. PSB and MIU groups were different only for drug purchase, as PSB were more likely to have a higher number of days of drug purchase from month 3 onwards. A reduction of 77% in the likelihood of experiencing incarceration was observed and this was comparable in PSB and MIU.

CONCLUSION

Switching non-responding buprenorphine patients to methadone can result in a major reduction in offences and incarceration rates. Increasing access to methadone, using more flexible models of care is urgent for clinical and public health reasons.

摘要

背景

接受丁丙诺啡治疗但效果不佳的患者仍可能继续从事与毒品相关的犯罪活动。将他们从丁丙诺啡转为美沙酮可能会减少犯罪行为。我们比较了从丁丙诺啡转为美沙酮治疗的患者(PSB)和新开始美沙酮维持治疗的患者(MIU)在开始美沙酮治疗前后的自我报告犯罪和监禁情况。

方法

通过电话访谈获取犯罪、监禁和其他信息。混合模型用于评估美沙酮治疗开始和 PSB 或 MIU 对(1)犯罪天数(毒品销售、毒品购买、其他犯罪)和(2)过去 6 个月监禁天数的影响。

结果

在至少有一次自我报告犯罪评估的 176 名患者中,51.7%是 PSB。接受美沙酮治疗与毒品销售或毒品购买犯罪天数减少显著相关,但与其他犯罪无关。PSB 和 MIU 组仅在毒品购买方面存在差异,因为从第 3 个月开始 PSB 更有可能有更多天数的毒品购买。观察到监禁的可能性降低了 77%,PSB 和 MIU 之间的情况相似。

结论

将丁丙诺啡治疗效果不佳的患者转为美沙酮治疗可显著降低犯罪和监禁率。出于临床和公共卫生的原因,迫切需要增加美沙酮的可及性,采用更灵活的护理模式。

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