Eichner J E, Kuller L H, Ferrell R E, Kamboh M I
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Genet Epidemiol. 1989;6(4):493-9. doi: 10.1002/gepi.1370060404.
Apolipoprotein A-IV (APO A-IV) is a major protein component of mesenteric lymph chylomicrons and very-low-density lipoproteins. It is found in plasma predominantly unassociated with major lipoprotein fractions and in high density lipoproteins. APO A-IV exhibits structural heterogeneity owing to two codominant alleles, APO A-IV1 and APO A-IV2, that occur in Caucasian and black populations. In vitro experimental evidence indicates that APO A-IV may be a cofactor for the lecithin:cholesterol acyltransferase enzyme, may be involved in reverse cholesterol transport, and may play an important role in the modulation of lipoprotein lipase activity. In this study we have investigated the effect of two APO A-IV phenotypes, APO A-IV 1-1 and APO A-IV 2-1, on quantitative lipid measures in a group of 453 white women being followed through menopause for changes in cardiovascular risk. At baseline all women were premenopausal. Of the nine lipid measures, triglycerides showed a marginally significant effect caused by phenotype. The APO A-IV 2-1 heterozygotes had lower average triglycerides than the 1-1 homozygotes (P = .053).
载脂蛋白A-IV（APO A-IV）是肠系膜淋巴乳糜微粒和极低密度脂蛋白的主要蛋白质成分。它主要以与主要脂蛋白组分不相关的形式存在于血浆中，也存在于高密度脂蛋白中。由于在白种人和黑人人群中出现的两个共显性等位基因APO A-IV1和APO A-IV2，APO A-IV表现出结构异质性。体外实验证据表明，APO A-IV可能是卵磷脂胆固醇酰基转移酶的辅因子，可能参与逆向胆固醇转运，并且可能在脂蛋白脂肪酶活性的调节中起重要作用。在本研究中，我们调查了两种APO A-IV表型，即APO A-IV 1-1和APO A-IV 2-1，对一组453名绝经期间心血管风险变化的白人女性定量脂质指标的影响。在基线时，所有女性均处于绝经前。在九项脂质指标中，甘油三酯显示出由表型引起的边缘显著效应。APO A-IV 2-1杂合子的平均甘油三酯水平低于1-1纯合子（P = 0.053）。
