Adler W H
Clinical Immunology Section, National Institute on Aging, Baltimore, Maryland.
Geriatrics. 1989 Aug;44 Suppl A:7-10.
Normal aging is accompanied by diverse changes in the immune system. Altered function of both T- and B-cells can be shown by losses in proliferative ability and interleukin-2 and interferon synthesis. Granulocyte function is decreased. Although there can be elevations in immunoprotein levels, antibody formation is decreased in most elderly individuals. Response to immunization varies greatly in the aged. This paper discusses the changes in immune function in the elderly, and the clinical implications of these changes.
正常衰老伴随着免疫系统的多种变化。T细胞和B细胞功能的改变可表现为增殖能力、白细胞介素-2和干扰素合成的丧失。粒细胞功能下降。虽然免疫蛋白水平可能会升高，但大多数老年人的抗体形成减少。老年人对免疫接种的反应差异很大。本文讨论了老年人免疫功能的变化以及这些变化的临床意义。
