产前接触低水平的甲基汞会改变孩子在 18 个月大时的精细运动技能。
Prenatal exposure to low-level methylmercury alters the child's fine motor skills at the age of 18 months.
机构信息
University Hospital Rijeka, University of Rijeka, Medical Faculty, Istarska 43, 51000 Rijeka, Croatia.
University Hospital Rijeka, Centre for Clinical, Health and Organizational Psychology, Istarska 43, 51000 Rijeka, Croatia.
出版信息
Environ Res. 2017 Jan;152:369-374. doi: 10.1016/j.envres.2016.10.011. Epub 2016 Oct 20.
OBJECTIVES
To compare motor, cognitive and language characteristics in children aged 18 months who were prenatally exposed to low-level methyl-mercury (MeHg), and to analyze the eventual differences in these characteristics in relation to cord blood THg concentration.
PATIENTS AND METHODS
The total number of 205 child-mother pairs was included in the study, and total cord blood mercury was measured in 198 of them. Out of the 198 already measured samples, 47 of them have also been tested for methyl-mercury in cord blood. Data regarding the 47 samples of MeHg levels has been used for calculating the correlation between cord blood THg and cord blood MeHg. MeHg and THg showed a significant correlation (r=0.95, p<0.05). One month after the delivery, mothers were asked to complete the questionnaire regarding socioeconomic factors, breastfeeding of their infants, and dietary habits during pregnancy. Neurodevelopmental assessment of motor, cognitive and language skills were conducted on 168 children using The Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Regarding the cord blood THg concentration, 135 children were divided in 4 quartile groups. Their neurodevelopmental characteristics have been compared.
RESULTS
The cord blood THg concentration median and inter-quartile range was 2.98ng/g (1.41-5.61ng/g). There was a negative correlation between cord blood THg concentration and fine motor skills (rho=-0.22, p=0.01). It is evident that children grouped in 2nd ,3rd and 4th quartile had statistically significant lower fine motor skills assessment related to those grouped in 1st quartile (2nd quartile -1.24, p=0.03; 3rd quartile -1.28, p=0.03; 4th quartile -1.45, p=0.01). The differences in fine motor skills assessments between children in 2nd and 3rd and 3rd and 4th quartile were not statistically significant.
CONCLUSION
Intrauterine exposure to low-level THg (MeHg) is associated with alterations in fine motor skills at the age of 18 months.
目的
比较 18 个月大的、孕期低水平甲基汞（MeHg）暴露的儿童的运动、认知和语言特征，并分析脐带血总汞（THg）浓度与这些特征之间的最终差异。
患者和方法
这项研究共纳入了 205 对母婴，其中 198 对的脐带血总汞进行了测量。在已经测量的 198 个样本中，有 47 个样本也检测了脐带血中的甲基汞。使用这 47 个 MeHg 水平样本的数据来计算脐带血 THg 和脐带血 MeHg 之间的相关性。MeHg 和 THg 呈显著相关性（r=0.95，p<0.05）。分娩后一个月，母亲们被要求完成一份关于社会经济因素、婴儿母乳喂养和孕期饮食习惯的问卷。使用贝利婴幼儿发育量表第三版（BSID-III）对 168 名儿童进行运动、认知和语言技能的神经发育评估。脐带血总汞浓度方面，135 名儿童被分为 4 个四分位组，比较他们的神经发育特征。
结果
脐带血总汞浓度中位数和四分位间距为 2.98ng/g（1.41-5.61ng/g）。脐带血总汞浓度与精细运动技能呈负相关（rho=-0.22，p=0.01）。显然，与第 1 四分位组相比，第 2、3 和 4 四分位组的儿童精细运动技能评估明显较低（第 2 四分位组-1.24，p=0.03；第 3 四分位组-1.28，p=0.03；第 4 四分位组-1.45，p=0.01）。第 2 四分位组和第 3 四分位组以及第 3 四分位组和第 4 四分位组儿童精细运动技能评估之间的差异无统计学意义。
结论
宫内低水平 THg（MeHg）暴露与 18 个月时精细运动技能的改变有关。
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