水飞蓟素及其在慢性病中的作用。

Silymarin and Its Role in Chronic Diseases.

作者信息

Jaggi Amteshwar S, Singh Nirmal

机构信息

Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University, Patiala, 147002, Punjab, India.

出版信息

Adv Exp Med Biol. 2016;929:25-44. doi: 10.1007/978-3-319-41342-6_2.

DOI:10.1007/978-3-319-41342-6_2

PMID:27771919

Abstract

Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine hemorrhage, and menstrual problems. In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders. An insight into modulation of cellular signaling by silymarin and its implication in various disorders such as liver disorders, inflammatory disorders, cancer, neurological disorders, skin diseases, and hypercholesterolemia is being provided.

摘要

水飞蓟素是水飞蓟（奶蓟）的活性成分，它是一种含C-25的黄酮木脂素。奶蓟具有许多传统价值，可作为蔬菜、沙拉、苦味滋补品，还可作为哺乳期母亲的催乳剂，用于治疗各种疾病，如肝脏并发症、抑郁症、消化不良、脾脏充血、静脉曲张、糖尿病、闭经、子宫出血和月经问题。在本章中，我们全面探讨了水飞蓟素在慢性疾病中的潜在作用。本文深入探讨了水飞蓟素对细胞信号传导的调节作用及其在各种疾病中的意义，如肝脏疾病、炎症性疾病、癌症、神经系统疾病、皮肤病和高胆固醇血症。