神经毒性酯酶在实验动物某些脑区中的分布。
Distribution of neurotoxic esterase in certain brain regions of laboratory animals.
作者信息
Matin M A, Sattar S, Khan S N, Husain K
机构信息
Industrial Toxicology Research Centre, Lucknow.
出版信息
Indian J Physiol Pharmacol. 1989 Apr-Jun;33(2):107-9.
Certain organophosphorous compounds caused the inhibition of 'neurotoxic esterase' present in central nervous system. The role of this enzyme is different from that of cholinesterase. The level of neurotoxic esterase in brain, corpus striatum and spinal cord of rats, mice, guineapigs and hens was measured. Maximum level of the enzyme was found in hens, followed by guineapigs, rats and mice in the order. The concentration of the enzyme was higher in corpus striatum greater than whole brain greater than spinal cord. The determination of the normal level of neurotoxic esterase may be useful in monitoring the exposure to organophosphorous compounds.
某些有机磷化合物会抑制中枢神经系统中存在的“神经毒性酯酶”。这种酶的作用与胆碱酯酶不同。对大鼠、小鼠、豚鼠和母鸡大脑、纹状体和脊髓中的神经毒性酯酶水平进行了测量。发现母鸡体内该酶的水平最高，其次依次是豚鼠、大鼠和小鼠。该酶在纹状体中的浓度高于全脑，全脑高于脊髓。测定神经毒性酯酶的正常水平可能有助于监测有机磷化合物的接触情况。
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