Husain K, Pant S C, Raza S K, Singh R, Das Gupta S
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior.
Indian J Physiol Pharmacol. 1995 Jan;39(1):47-50.
Hens treated with Mipafox (10 mg/kg, sc), sarin (50 micrograms/kg, sc) or parathion (1 mg/kg, sc) daily for 10 days exhibited severe, moderate and no ataxia respectively on 14th day after the start of exposure. The neurotoxic esterase (NTE) activity was significantly inhibited in the brain, spinal cord and platelets of hens treated with mipafox or sarin whereas no change was noticed with parathion treatment. All three compounds significantly inhibited acetylcholinesterase (AChE) activity in the platelets. Spinal cord of hens treated with mipafox, sarin or parathion showed axonal degeneration heavy, moderate and none respectively. It is concluded that repeated administration of equitoxic doses of mipafox, sarin and parathion to hens are marked, moderate and non-delayed neurotoxic respectively.
用丙氟磷（10毫克/千克，皮下注射）、沙林（50微克/千克，皮下注射）或对硫磷（1毫克/千克，皮下注射）每日处理母鸡，持续10天，在开始接触后的第14天，分别表现出严重、中度和无共济失调。在用丙氟磷或沙林处理的母鸡的脑、脊髓和血小板中，神经毒性酯酶（NTE）活性显著受到抑制，而用对硫磷处理则未观察到变化。所有三种化合物均显著抑制血小板中的乙酰胆碱酯酶（AChE）活性。用丙氟磷、沙林或对硫磷处理的母鸡的脊髓分别显示出严重、中度和无轴突变性。结论是，对母鸡重复给予等毒性剂量的丙氟磷、沙林和对硫磷分别具有明显、中度和非延迟性神经毒性。
